Tegumental histological effects of Mirazid® and myrrh volatile oil on adult Fasciola gigantica

Ahmad Mohamed Massoud; Hatem Abdel Mawgoud Shalaby; Rabab Mohamed El Khateeb; Mona Said Mahmoud; Mohamed Abdel Aziz Kutkat

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Tegumental histological effects of Mirazid® and myrrh volatile oil on adult Fasciola gigantica

机译：Mirazid®和没药挥发油对成年Fasciola gigantica的皮肤组织学影响

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To evaluated the histological changes within the tegument of adult Fasciola gigantica (F. gigantica) that led to the gross changes that were visible externally. Methods: The effects of oleoresin extract of myrrh (Mirazid ® ), myrrh volatile oil and triclabendazole sulphoxide (reference drug) on the tegumental structure of adult F. gigantica following treatment in vitro had been determined by light microscopy. Results: The internal changes in the tegument observed in this study were compatible with surface changes seen in the previous scanning electron microscopy study, using the same drugs. The swelling of tegumental syncytium was a particular feature of their action, but its level was much greater with myrrh volatile oil, in which vacuolization of the tegument and loss of spines were observed. Conclusions: The present study demonstrated the fasciocidal properties of Mirazid ® oleoresin extract, and it might be possible to reinforce its fasciocidal activity by increasing its content of myrrh volatile oil.

机译：若要评估成年的Fasciola gigantica（F. gigantica）皮下的组织学变化，从而导致在外部可见的总体变化。方法：通过光学显微镜确定了没药的油树脂提取物（Mirazid®），没药挥发油和三氯苯达唑亚砜（参考药物）对成年巨人成虫的外皮结构的影响。结果：在本研究中观察到的外皮的内部变化与使用相同药物的先前扫描电子显微镜研究中观察到的表面变化相吻合。皮肤合胞体的肿胀是其作用的一个特殊特征，但没药挥发油的水平更高，其中观察到了皮肤的空泡化和脊柱的丧失。结论：本研究证明了Mirazid®油树脂提取物的杀菌特性，并可能通过增加没药挥发油的含量来增强杀菌活性。

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《亚太热带生物医学杂志（英文版）》 |2013年第6期|501-504|共4页
作者
Ahmad Mohamed Massoud; Hatem Abdel Mawgoud Shalaby; Rabab Mohamed El Khateeb; Mona Said Mahmoud; Mohamed Abdel Aziz Kutkat;
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作者单位

Tropical Medicine Department, Faculty of Medicine, Al-Azhar University, Egypt;

Parasitology and Animal Diseases Department, National Research Center, Giza, Egypt;

Parasitology and Animal Diseases Department, National Research Center, Giza, Egypt;

Parasitology and Animal Diseases Department, National Research Center, Giza, Egypt;

Poultry Diseases Department, National Research Center, Giza, Egypt;

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Tegumental histological effects of Mirazid® and myrrh volatile oil on adult Fasciola gigantica

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