The emergence of drug resistant HIV variants and novel anti-retroviral therapy

Koosha Paydary; Parisa Khaghani; Sahra Emamzadeh-Fard; SeyedAhmad SeyedAlinaghi; Kazem Baesi

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The emergence of drug resistant HIV variants and novel anti-retroviral therapy

机译：耐药HIV变异体和新型抗逆转录病毒疗法的出现

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After its identification in 1980s, HIV has infected more than 30 million people worldwide. In the era of highly active anti-retroviral therapy, anti-retroviral drug resistance results from insufficient anti-retroviral pressure, which may lead to treatment failure. Preliminary studies support the idea that anti-retroviral drug resistance has evolved largely as a result of low-adherence of patients to therapy and extensive use of anti-retroviral drugs in the developed world;however, a highly heterogeneous horde of viral quasi-species are currently circulating in developing nations. Thus, the prioritizing of strategies adopted in such two worlds should be quite different considering the varying anti-retroviral drug resistance prevalence. In this article, we explore differences in anti-retroviral drug resistance patterns between developed and developing countries, as they represent two distinct ecological niches of HIV from an evolutionary standpoint.

机译：自1980年代被发现以来，艾滋病毒已感染了全球超过3000万人。在高效抗逆转录病毒疗法时代，抗逆转录病毒药物耐药性是由于抗逆转录病毒压力不足而导致的，可能导致治疗失败。初步研究支持以下观点：在发达国家，患者对治疗的依从性较低以及抗逆转录病毒药物的广泛使用已导致抗逆转录病毒药物耐药性的发展;然而，高度准异的病毒准物种目前在发展中国家流通。因此，考虑到抗逆转录病毒药物耐药性的变化，在这两个领域采用的策略的优先次序应该有很大不同。在本文中，我们探讨了发达国家和发展中国家在抗逆转录病毒药物耐药性模式上的差异，因为从进化的角度来看，它们代表了两个不同的艾滋病毒生态生态位。

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《亚太热带生物医学杂志（英文版）》 |2013年第7期|515-522|共8页
作者
Koosha Paydary; Parisa Khaghani; Sahra Emamzadeh-Fard; SeyedAhmad SeyedAlinaghi; Kazem Baesi;
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Iranian Research Center for HIV/AIDS IRCHA, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran;

Iranian Research Center for HIV/AIDS IRCHA, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran;

Iranian Research Center for HIV/AIDS IRCHA, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran;

Iranian Research Center for HIV/AIDS IRCHA, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran;

Iranian Research Center for HIV/AIDS IRCHA, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran;

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The emergence of drug resistant HIV variants and novel anti-retroviral therapy

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