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首页> 外文期刊>亚太热带生物医学杂志（英文版） >Saponins-rich fraction of Calotropis procera leaves elicit no antitrypanosomal activity in a rat model
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Saponins-rich fraction of Calotropis procera leaves elicit no antitrypanosomal activity in a rat model

机译：大鼠模型中富含Catrotropis procera叶片的皂苷成分未引起抗锥虫活性

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Objective:To examine the in vitro and in vivo anti-Trypanosoma evansi (T. evansi ) activity of saponins-rich fraction of Calotropis procera (cpsf) leaves as well as the effect of the fraction on the parasite-induced anemia. Methods:A 60-minutes time course experiment was conducted with various concentrations of the fraction using a 96-well microtiter plate technique, and subsequently used to treat experimentally T. evansi infected rats at 100 and 200 mg/kg body weight. Index of anemia was analyzed in all animals during the experiment. Results:The cpsf did not demonstrate an in vitro antitrypanosomal activity. Further, the cpsf treatments did not significantly (P>0.05) keep the parasites lower than the infected untreated groups. At the end of the experiment, all T. evansi infected rats developed anemia whose severity was not significantly (P>0.05) ameliorated by the cpsf treatment. Conclusions:It was concluded that saponins derived from Calotropis procera leaves could not elicit in vitro and in vivo activities against T. evansi.
机译：目的：研究淡水Calotropis procera（cpsf）叶片中富含皂苷的组分的体外和体内抗伊氏锥虫（T. evansi）活性，以及​​该组分对寄生虫性贫血的影响。方法：采用96孔微量滴定板技术，以不同浓度的级分进行了60分钟的时程实验，随后用于以100和200 mg / kg体重的实验处理经伊文氏锥虫感染的大鼠。在实验过程中分析了所有动物的贫血指数。结果：cpsf没有显示出体外抗锥虫活性。此外，cpsf处理没有显着（P> 0.05）使寄生虫低于感染的未处理组。在实验结束时，所有经伊凡丝锥虫感染的大鼠均出现贫血，其严重程度通过cpsf治疗并没有明显改善（P> 0.05）。结论：得出的结论是，来自东方花菱草叶的皂苷不能在体内和体外产生抗伊凡丝酵母的活性。

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