Anti-trypanosomal effect of Peristrophe bicalyculata extract on Trypanosoma brucei brucei-infected rats

Abdulazeez Mansurah Abimbola; Ibrahim Abdulrazak Baba; Edibo Zakari Yenusa; Sidali Joseph Omanibe; Idris Habeeb Oladimeji

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Anti-trypanosomal effect of Peristrophe bicalyculata extract on Trypanosoma brucei brucei-infected rats

机译：紫花Peristrophe biicalyculata提取物对布鲁氏锥虫布鲁氏菌感染大鼠的抗锥虫作用

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Objective: To investigate the in vitro and in vivo effect of whole plant extracts of Peristrophe bicalyculata on Trypanosoma brucei brucei-infected rats. Methods: The experiment was divided into two phases: In the first phase, the anti-trypanosomal activity of the hot water, cold water, methanol and butanol extracts of the whole plant were determined by incubating with Trypanosoma brucei brucei. The cold water extract was partially-purified and the anti-trypanosomal activity of the fractions determined. In the second phase, Trypanosoma brucei brucei-infected rats were treated with fraction 2c for nine days. Packed cell volume (PCV), high density lipoprotein (HDL), low density lipoprotein (LDL), total cholesterol (TC), triacylglycerol (TAG), aspartate aminotransferase, alanine aminotransferases (ALT), alkaline phosphatase (ALP), total and direct bilirubin levels were determined at the end of the experiment. Results:Cold water extract immobilized 90%of the parasites after 60 min of incubation, and fraction 2c completely immobilized the parasites after 35 min. It significantly increased PCV in Trypanosoma brucei brucei-infected rats. Decreased TC, TAG, HDL and LDL levels of infected rats increased significantly when rats were treated with the fraction, while elevated levels of total bilirubin and ALT also decreased. The difference in urea, direct bilirubin and ALP was not significant when infected rats were compared to rats in other groups. Conclusions:The ability of the plant to ameliorate the infection-induced biochemical changes calls for detailed investigation of the potentials of the plant for antitrypanosomiasis drug delivery.

机译：目的：研究紫茎泽兰全植物提取物对布鲁氏锥虫感染的大鼠的体内外作用。方法：将实验分为两个阶段：第一阶段，与布鲁氏锥虫一起温育确定整个植物的热水，冷水，甲醇和丁醇提取物的抗锥虫活性。将冷水提取物部分纯化，并测定级分的抗锥虫活性。在第二阶段，将布鲁氏锥虫感染的大鼠用2c组分处理9天。填充细胞体积（PCV），高密度脂蛋白（HDL），低密度脂蛋白（LDL），总胆固醇（TC），三酰甘油（TAG），天冬氨酸转氨酶，丙氨酸转氨酶（ALT），碱性磷酸酶（ALP），总和直接实验结束时测定胆红素水平。结果：孵育60分钟后，冷水提取物固定了90％的寄生虫，而级分2c在35分钟后完全固定了寄生虫。它可显着提高布鲁氏锥虫感染的大鼠的PCV。用该级分处理大鼠后，被感染大鼠的TC，TAG，HDL和LDL水平降低明显增加，而总胆红素和ALT水平升高也降低。当将感染的大鼠与其他组的大鼠进行比较时，尿素，直接胆红素和ALP的差异不显着。结论：植物改善感染引起的生化变化的能力要求详细研究植物抗锥虫病药物传递的潜力。

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《亚太热带生物医学杂志（英文版）》 |2013年第7期|523-531|共9页
作者
Abdulazeez Mansurah Abimbola; Ibrahim Abdulrazak Baba; Edibo Zakari Yenusa; Sidali Joseph Omanibe; Idris Habeeb Oladimeji;
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Department of Biochemistry, Faculty of Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria;

Department of Biochemistry, Faculty of Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria;

Department of Biochemistry, Faculty of Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria;

Department of Biochemistry, Faculty of Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria;

Department of Biochemistry, Faculty of Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria;

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Anti-trypanosomal effect of Peristrophe bicalyculata extract on Trypanosoma brucei brucei-infected rats

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