Anti-ulcer activity of Ficus religiosa leaf ethanolic extract

Marslin Gregory; B Divya; Revina Ann Mary; M M Hipolith Viji; V K Kalaichelvan; V Palanivel

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Anti-ulcer activity of Ficus religiosa leaf ethanolic extract

机译：榕榕叶片乙醇提取物的抗溃疡活性

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Objective:To evaluate the anti-ulcer activity and acute toxicity of Ficus religiosa (F. religiosa) leaf ethanolic extract in animal models. Methods:Anti-ulcer activity of F. religiosa ethanolic extract (250 and 500 mg/kg body weight) was studied on stress induced ulcer animal models. Ranitidine was used as standard. The anti-ulcer activity of F. religiosa was evaluated with the help of ulcer area and histopatholgical examination. Preliminary phyto-chemical screening and acute toxicity studies of F. religiosa also carried out. Results: Results showed that the extract treatments prevented ulcer area and gastric secretion in a dose-dependent manner. Administration of 2 000 mg/kg extract did not show any acute toxicity in albino mice. Preliminary phytochemical analysis identified the presence of flavonoids in the ethanolic extract of F. religiosa. Conclusions: The extract is non-toxic even at relatively high concentrations. The anti-ulcer activity is probably due to the presence of flavanoids.

机译：目的：评价无花果叶乙醇提取物在动物模型中的抗溃疡活性和急性毒性。方法：在应激性溃疡动物模型上研究了菩提树乙醇提取物（250和500 mg / kg体重）的抗溃疡活性。雷尼替丁用作标准品。借助溃疡区域和组织病理学检查评估了菩提树的抗溃疡活性。还进行了菩提树的初步植物化学筛选和急性毒性研究。结果：结果表明，提取物处理可剂量依赖性地预防溃疡面积和胃液分泌。给予2000 mg / kg提取物在白化病小鼠中未显示任何急性毒性。初步的植物化学分析确定了桔梗乙醇提取物中黄酮类化合物的存在。结论：该提取物即使在较高浓度下也无毒。抗溃疡活性可能是由于黄酮类化合物的存在。

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《亚太热带生物医学杂志（英文版）》 |2013年第7期|554-556|共3页
作者
Marslin Gregory; B Divya; Revina Ann Mary; M M Hipolith Viji; V K Kalaichelvan; V Palanivel;
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Department of pharmacology, Annamalai University, Chidambaram, India;

Padmavathi College of Pharmacy and Research Institute, Periyanahalli, Dharmapuri, Tamilnadu, India;

Department of Nursing Science, A.J College of Nursing, Chennai, Tamilnadu, India;

Department of Phytochemistry, Natural Remedies Research lab, Bangalore, Karnataka, India;

Department of pharmacology, Annamalai University, Chidambaram, India;

Department of pharmacology, Annamalai University, Chidambaram, India;

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Anti-ulcer activity of Ficus religiosa leaf ethanolic extract

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