Exploring a natural MDR reversal agent：potential of medicinal food supplement Nerium oleander leaf distillate

Meltem Demirel Kars; Ufuk Gndz; Kamil ney; Ahmet Levent Ba

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Exploring a natural MDR reversal agent：potential of medicinal food supplement Nerium oleander leaf distillate

机译：探索天然的耐多药逆转剂：药用补品的潜力夹竹桃叶馏出物

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Objective: To investigate the molecular effects of Nerium oleander leaf distillate on paclitaxel and vincristine resistant (MCF-7/Pac and MCF-7/Vinc) cells and sensitive (MCF-7/S) cell lines. Methods: Nerium oleander (N. oleander) leaf extract was obtained by hydrodistillation method.The toxicological effects of N. oleander distillate, previously suggested as medicinal food supplement, on drug resistant cells were evaluated by XTT tests. MDR modulation potential of the plant material was evaluated by flow cytometry and fluorescent microscopy. Paclitaxel and vincristine were applied to the sublines in combination with N. oleander distillate. Results:Fractional inhibitory indices show that N. oleander distillate did not increase the antiproliferative effects of anticancer drugs. N. oleander treatment in to MCF-7/Pac and MCF-7/Vinc did not inhibit P-gp activity and MDR1 gene expression level. Conclusions: As a result it may be suggested that although N. oleander distillate has some medicinal effects as food supplement it may not be suitable as an MDR modulator for drug resistant breast cancer cells.

机译：目的：研究夹竹桃叶馏出物对紫杉醇和长春新碱耐药（MCF-7 / Pac和MCF-7 / Vinc）细胞和敏感（MCF-7 / S）细胞系的分子影响。方法：采用水蒸馏法提取夹竹桃叶提取物，通过XTT试验评估了以前作为药用食品补充品的夹竹桃馏出物对耐药细胞的毒理作用。通过流式细胞术和荧光显微镜评价植物材料的MDR调节潜力。将紫杉醇和长春新碱与夹竹桃油分馏物一起应用于亚系。结果：分数抑制指数表明，夹竹桃馏出物没有增加抗癌药的抗增殖作用。夹竹桃对MCF-7 / Pac和MCF-7 / Vinc的处理不会抑制P-gp活性和MDR1基因表达水平。结论：结果表明，尽管夹竹桃蒸馏物作为食品补充剂具有一定的药理作用，但它可能不适合作为耐药性乳腺癌细胞的MDR调节剂。

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《亚太热带生物医学杂志（英文版）》 |2013年第8期|644-649|共6页
作者
Meltem Demirel Kars; Ufuk Gndz; Kamil ney; Ahmet Levent Ba;
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作者单位

Selçuk University, Sarayönü Vocational High School, 42430 Konya, Turkey;

Middle East Technical University, Department of Biological Sciences, 06531 Ankara, Turkey;

Selcuk University, Faculty of Veterinary Medicine, Department of Toxicology and Pharmacology, 42075, Konya, Turkey;

Selcuk University, Faculty of Veterinary Medicine, Department of Toxicology and Pharmacology, 42075, Konya, Turkey;

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Exploring a natural MDR reversal agent：potential of medicinal food supplement Nerium oleander leaf distillate

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