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首页> 外文期刊>亚太热带生物医学杂志（英文版） >A comparative study of the antioxidant, antimicrobial, cytotoxic and thrombolytic potential of the fruits and leaves of Spondias dulcis
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A comparative study of the antioxidant, antimicrobial, cytotoxic and thrombolytic potential of the fruits and leaves of Spondias dulcis

机译：番石榴果实和叶片的抗氧化，抗微生物，细胞毒性和溶栓潜力的比较研究

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Objective:To investigate the antioxidant, antimicrobial, cytotoxic and thrombolytic property of the fruits and leaves of Spondias dulcis (S. dulcis). Methods:Methanolic extracts of fruits and leaves of S. dulcis were partitioned with chloroform and dichloromethane. The antioxidant potential of the crude extract and partitioned fractions were evaluated in terms of total phenolic content, total flavonoid content, DPPH radical scavenging potential, reducing potential and total antioxidant capacity by specific standard procedures. The antimicrobial activity was evaluated using disc diffusion method. The cytotoxicity was evaluated by using brine shrimp lethality bioassay and compared with vincristine sulfate. The thrombolytic activity was compared with streptokinase. Results:The methanolic fruit extract exhibited the highest phenolic content, flavonoid content and antioxidant capacity, among the other extracts, with the highest DPPH radical scavenging activity at a concentration of 10 µg/mL (IC50: 1.91 µg/mL) and maximum reducing power at a concentration of 100 µg/mL (EC50: 3.58 µg/mL). Though all extract showed moderate antimicrobial activity against the bacterial strains, weak or no activity against fungus. The range of LC50 value of all extracts was 1.335-14.057 µg/mL which was far lower than the cut off index for cytotoxicity. All extracts exhibited statistically significant (P<0.001) thrombolytic activity. Conclusions:Our study suggested that S. dulcis exhibits antimicrobial activities against a wide variety of strains while it possesses significant antioxidant, cytotoxic and thrombolytic activity.
机译：目的：研究Spondias dulcis（S. dulcis）果实和叶片的抗氧化，抗菌，细胞毒性和溶栓特性。 方法：将桔梗果实和叶片的甲醇提取物在氯仿和二氯甲烷之间分配。通过特定的标准程序，根据总酚含量，总黄酮含量，DPPH自由基清除能力，还原电位和总抗氧化剂能力，对粗提物和分配的馏分的抗氧化剂潜力进行了评估。使用盘扩散法评价抗菌活性。通过使用盐水虾杀伤力生物测定法评估细胞毒性，并与硫酸长春新碱进行比较。将溶栓活性与链激酶进行比较。 结果：含甲醇的水果提取物表现出最高的酚含量，类黄酮含量和抗氧化能力，在其他提取物中表现出最高的DPPH自由基清除活性，浓度为10 µg / mL（IC50：1.91 µg / mL），并且在100 µg / mL的浓度下最大还原能力（EC50：3.58 µg / mL）。尽管所有提取物对细菌菌株均显示中等的抗菌活性，但对真菌的活性较弱或没有。所有提取物的LC50值范围为1.335-14.057 µg / mL，远低于细胞毒性的临界值。所有提取物均显示出统计学上显着的（P <0.001）溶栓活性。 结论：我们的研究表明，杜氏链球菌对多种菌株均具有抗菌活性，同时具有显着的抗氧化剂，细胞毒性和溶栓活性。

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