Anti-inflammatory and antioxidant activities of ethanolic extract of aerial parts of Vernonia patula (Dryand.) Merr.

Arpona Hira; Shubhra Kanti Dey; Md Sariful Islam Howlader; Arif Ahmed; Hemayet Hossain; Ismet Ara Jahan

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Anti-inflammatory and antioxidant activities of ethanolic extract of aerial parts of Vernonia patula (Dryand.) Merr.

机译：疣状Vernonia patula（Dryand。）Merr的乙醇提取物的抗炎和抗氧化活性。

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Objective:To investigate the inflammatory and antioxidant activities of ethanolic extract of aerial part of Vernonia patula (Dryand.) Merr (EAV). Methods:The anti-inflammatory activity of EAV was studied using carrageenan and histamine-induced rat paw edema test at different doses (100, 200 and 400 mg/kg body weight). DPPH free radical scavenging, nitric oxide scavenging, reducing power and Fe2+ion chelating ability were used for determining antioxidant activities. Results: The EAV, at the dose of 400 mg/kg, showed a significant anti-inflammatory activity (P<0.01) both in the carrageenan and histamine-induced oedema test models in rats, showing 62.86%and 64.42%reduction in the paw volume comparable to that produced by the standard drug indomethacin (67.26%and 66.01%) at 5 h respectively. In DPPH free radical scavenging test, IC50 value for EAV was found fairly significant 36.59 µg/mL when compared to the IC50 value of the reference standards ascorbic acid 8.97 µg/mL. The IC50 values of the extract and ascorbic acid were 47.72 and 12.39 µg/mL, respectively in nitric oxide scavenging assay. The IC50 value of the EAV (33.59 µg/mL) as percentage of Fe2+ion chelating ability was also found significant compared to that of EDTA (9.16 µg/mL). The maximum absorbance for reducing power assay was found to be 1.928 at 100 µg/mL when compared to 2.449 for standard ascorbic acid. The total phenolic content was 198.81 mg/g of gallic acid equivalent. Acute toxicity test showed that the plant might be safe for pharmacological uses up to a dose level of 3 200 mg/kg of body weight in rats. Conclusions: Therefore, the obtained results suggest the acute anti-inflammatory and antioxidant activities of the EAV and thus provide the scientific basis for the traditional uses of this plant part as a remedy for inflammations.

机译：目的：研究pat虫（Vernonia patula）（Dryand。）Merr（EAV）气生部分的乙醇提取物的炎症和抗氧化活性。方法：采用角叉菜胶和组胺诱导的大鼠爪水肿试验，以不同剂量（100、200和400 mg / kg体重）研究EAV的抗炎活性。用DPPH自由基清除，一氧化氮清除，还原能力和Fe 2+离子螯合能力确定抗氧化活性。结果：EAV剂量为400 mg / kg时，在角叉菜胶和组胺诱导的水肿测试模型中均显示出显着的抗炎活性（P <0.01），分别降低了62.86％和64.42％足量与标准药物消炎痛在5 h时产生的足量（分别为67.26％和66.01％）相当。在DPPH自由基清除测试中，与参考标准抗坏血酸8.97 µg / mL的IC50值相比，EAV的IC50值相当显着，为36.59 µg / mL。一氧化氮清除试验中提取物和抗坏血酸的IC50值分别为47.72和12.39 µg / mL。与EDTA（9.16 µg / mL）相比，EAV的IC50值（33.59 µg / mL）也表现出显着的Fe2 +离子螯合能力百分比。与标准抗坏血酸的2.449相比，100 µg / mL的还原力测定法的最大吸光度为1.928。总酚含量为198.81 mg / g没食子酸当量。急性毒性试验表明，在大鼠中，这种植物药剂量最高为3200 mg / kg体重时，可安全用于药理用途。结论：因此，获得的结果表明EAV具有急性的抗炎和抗氧化活性，从而为该植物部分的传统用途作为炎症疗法提供了科学依据。

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《亚太热带生物医学杂志（英文版）》 |2013年第10期|798-805|共8页
作者
Arpona Hira; Shubhra Kanti Dey; Md Sariful Islam Howlader; Arif Ahmed; Hemayet Hossain; Ismet Ara Jahan;
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Pharmacy Discipline, Life Science School, Khulna University, Khulna-9208, Bangladesh;

Pharmacy Discipline, Life Science School, Khulna University, Khulna-9208, Bangladesh;

Department of Pharmacy, World University of Bangladesh, Dhaka-1205, Bangladesh;

Pharmacy Discipline, Life Science School, Khulna University, Khulna-9208, Bangladesh;

BCSIR Laboratories, Dhaka, Bangladesh Council of Scientific and Industrial Research, Dr. Qudrat-E-Khuda Road, Dhaka-1205, Bangladesh;

BCSIR Laboratories, Dhaka, Bangladesh Council of Scientific and Industrial Research, Dr. Qudrat-E-Khuda Road, Dhaka-1205, Bangladesh;

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Anti-inflammatory and antioxidant activities of ethanolic extract of aerial parts of Vernonia patula (Dryand.) Merr.

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