Hepatoprotective effect of leaves of Erythroxylum monogynum Roxb. on paracetamol induced toxicity

Sabeena Hussain Syed; Ajay Gajanan Namdeo

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Hepatoprotective effect of leaves of Erythroxylum monogynum Roxb. on paracetamol induced toxicity

机译：丹参叶的肝保护作用。对扑热息痛诱发的毒性

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Objective: To investigate the hepatoprotective activity of methanolic extract of leaves ofErythroxylum monogynum Methods: Methanolic extract of leaves of E. monogynum was given in doses of 100 mg/kg, 200 mg/kg and 400 mg/kg for 7 d and toxicity was induced by paracetamol (2 mg/kg) on Day 8. Silymarin (50 mg/kg) was used as reference standard. After 24 h of toxicity induction blood samples were collected from retro-orbital plexsus and analyzed for serum parameters like serum glutamic pyruvic transaminase, serum glutamic oxaloacetate transaminse, alkaline phosphatase and total bilirubin. Livers isolated were studied for histopathological changes. (E. monogynum) on paracetamol induced toxicity. Results: Phytochemical analysis of methanolic extract of E. monogynum leaves showed the presence of carbohydrates, flavonoids, phenols and saponins. Prior administration of this extract restored the elevated levels serum markers as compared to toxic group which is also confirmed by the histopathological changes observed.Conclusions:The present study showed that methanolic extract of leaves of E. monogynum possess hepatoprotective action against paracetamol induced hepatotoxicity.

机译：目的：研究独脚莲叶片甲醇提取物的保肝活性。方法：以100 mg / kg，200 mg / kg和400 mg / kg的剂量给予独脚莲叶片的甲醇提取物，持续7 d，并诱导毒性。在第8天通过对乙酰氨基酚（2mg / kg）通过水飞蓟素（50mg / kg）作为参考标准。毒性诱导后24小时，从眼眶后神经丛收集血液样品，并分析血清参数，例如血清谷氨酸丙酮酸转氨酶，血清谷草草酰乙酸转氨酶，碱性磷酸酶和总胆红素。研究了分离的肝脏的组织病理学变化。（E. monogynum）对扑热息痛引起的毒性。结果：大叶紫茎泽兰的甲醇提取物的植物化学分析表明，存在碳水化合物，类黄酮，酚和皂苷。与毒性组相比，该提取物在给药前恢复了较高水平的血清标志物，这也被观察到的组织病理学改变所证实。

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《亚太热带生物医学杂志（英文版）》 |2013年第11期|877-881|共5页
作者
Sabeena Hussain Syed; Ajay Gajanan Namdeo;
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Department of Pharmacognosy, Bharati Vidyapeeth Deemed University, Poona College of Pharmacy, Pune- 411038, India;

Department of Pharmacognosy, Bharati Vidyapeeth Deemed University, Poona College of Pharmacy, Pune- 411038, India;

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Hepatoprotective effect of leaves of Erythroxylum monogynum Roxb. on paracetamol induced toxicity

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