Comparison of lipid profile in different grades of non-alcoholic fatty liver disease diagnosed on ultrasound

Dhumal Uttareshvar Mahaling; Madole Mahesh Basavaraj; Aher Jagdish Bika

摘要

Objective: To detect and compare serum lipid abnormalities in patients diagnosed with different grades of non-alcoholic fatty liver on ultrasonography.Methods:A total of 70 cases which included 30 males and 40 females, diagnosed as non-alcoholic fatty liver disease (NAFLD) on ultrasound were investigated with serum lipid profile. Then a comparison of lipid abnormalities between different grades of fatty liver diagnosed on ultrasound was done. P value was calculated by using analysis of variance test (ANOVA) and P value <0.05 was considered as statistically significant.Results:Out of 70 cases which were diagnosed as NAFLD cases were 47.15%, grade II were 42.85% and grade III were 10%. The mean age of the patients was 49.14 years. Male to female ratio was 3:4. Serum triglycerides, total cholesterol, LDL and VLDL levels were raised in 67.14%, 45.71% 34.28%, 25.71% of cases respectively. Low serum HDL levels were seen in 62.85% of patients. On statistical analysis we found increasing grades of NAFLD were significantly associated with increasing values of total cholesterol (P value-0.001), LDL (P value-0.000) and VLDL (P value-0.003) and decreasing HDL (P value-0.000).Conclusion:Most of the patients of NAFLD in India is asymptomatic, non-diabetic and on ultrasonography, grade I NAFLD non-hypertensive. Though liver biopsy is the gold standard method for diagnosis of NAFLD, Ultrasonography which is non-invasive, simple tool, can be used for the early detection of NAFLD in asymptomatic patients.

机译：目的：通过超声检查发现和比较不同等级的非酒精性脂肪肝患者的血脂异常。方法：共计70例，其中男性30例，女性40例，被诊断为非酒精性脂肪性肝病（NAFLD）超声检查血清脂质状况。然后对超声诊断出的不同级别的脂肪肝之间的脂质异常进行比较。 P值采用方差分析（ANOVA）计算，P值<0.05被认为具有统计学意义。结果：70例NAFLD病例中，诊断率为47.15％，II级为42.85％，III级为10 ％。患者的平均年龄为49.14岁。男女比例为3：4。血清甘油三酸酯，总胆固醇，LDL和VLDL水平分别升高了67.14％，45.71％，34.28％和25.71％。 62.85％的患者血清HDL水平较低。在统计分析中，我们发现NAFLD等级的升高与总胆固醇（P值0.001），LDL（P值0.000）和VLDL（P值0.003）和HDL降低（P值0.000）的增加显着相关。结论：印度的NAFLD患者大多数无症状，无糖尿病，在超声检查中，I级NAFLD非高血压。尽管肝活检是诊断NAFLD的金标准方法，但无创，简单的超声检查可用于无症状患者NAFLD的早期检测。

Comparison of lipid profile in different grades of non-alcoholic fatty liver disease diagnosed on ultrasound

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