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首页> 中文期刊> 《亚太热带生物医学杂志（英文版）》 >Renoprotective effect of umbelliferone in high-fat diet/streptozotocin-induced type 2 diabetic rats

Renoprotective effect of umbelliferone in high-fat diet/streptozotocin-induced type 2 diabetic rats

         
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Objective:To evaluate the renoprotective effect of umbelliferone in high-fat diet/streptozotocin-induced type 2 diabetic rats.Methods:We established a streptozotocin-induced type 2 diabetic model in male Wistar rats.The rats were fed with high-fat diet(45 kcal%lard fat)and injected with 35 mg/kg streptozotocin.Diabetic rats were treated with umbelliferone for 8 weeks.At the end of the experimental period,the serum and kidney were used for measuring biochemical parameters,protein expression and histological analysis.Results:After 8-week treatment,umbelliferone decreased fasting plasma glucose,concentrations of malondialdehyde and monocyte chemoattractant protein-1 in the plasma and tissues.It also significantly reduced serum creatinine,blood urea nitrogen,serum advanced glycation end products,as well as kidney weight in type 2 diabetic rats(P<0.05).Moreover,umbelliferone reduced the 24-h urine albumin,but increased 24-h urine creatinine excretion(P<0.05).In renal protein expression,umbelliferone decreased the levels of transforming growth factor-β1 and fibronectin while increasing the levels of superoxide dismutase and catalase(P<0.05).Renal histological examination revealed an enlarged glomerular size in diabetic rats,which was smaller in umbelliferone-treated diabetic rats.Conclusions:Umbelliferone alleviates renal dysfunction in diabetes via decreasing hyperglycemia,oxidative stress,inflammation and glycation.

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