Resveratrol downregulates TGF-β1 and Smad3 expression and attenuates oxidative stress in CCl4-induced kidney damage in rats

Saeed Mohammadi; Jamshid Karimi; Heidar Tavilani; Iraj Khodadadi; Roohollah Mohseni; Mohammad Hashemnia

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Resveratrol downregulates TGF-β1 and Smad3 expression and attenuates oxidative stress in CCl4-induced kidney damage in rats

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Objective:To evaluate the effect of resveratrol against CCl4-induced nephrotoxicity.Methods:Forty-two male Wistar rats were divided into seven groups randomly.After six weeks,kidney weight,body weight,blood urea,serum creatinine,oxidative stress markers,and gene expression of renal transforming growth factor-beta1(TGF-β1),TGF-βreceptor type 1(TGF-βR1)and Smad3 were determined.In addition,the protein level of TGF-β1 in the tissue lysate was measured.Results:Resveratrol had a protective role in renal tissue by the improvement of antioxidant balance and reduction of renal parameters such as creatinine and urea(P<0.001).In addition,the renal m RNA level of TGF-β1,TGF-βR1,Smad3,as well as the protein level of TGF-β1 were decreased in rats treated with resveratrol(P<0.001),compared to the CCl4 group.Conclusions:Overall,resveratrol shows a protective effect against nephrotoxicity in CCl4 treated rats by reducing oxidative stress status and modulating the TGF-βsignaling.

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《亚太热带生物医学杂志（英文版）》 |2020年第9期|397-402|共6页
作者
Saeed Mohammadi; Jamshid Karimi; Heidar Tavilani; Iraj Khodadadi; Roohollah Mohseni; Mohammad Hashemnia;
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Department of Clinical Biochemistry. Hamadan University of Medical Sciences Hamadan Iran;

Department of Clinical Biochemistry. Hamadan University of Medical Sciences Hamadan Iran;

Nutrition Health Research Center Hamadan University of Medical Sciences Hamadan Iran;

Department of Clinical Biochemistry. Hamadan University of Medical Sciences Hamadan Iran;

Department of Clinical Biochemistry. Hamadan University of Medical Sciences Hamadan Iran;

Clinical Biochemistry Research center Basic Health Sciences Institute Shahrekord University of Medical Sciences Shahrekord Iran;

Department of Pathobiology Veterinary Medicine Faculty Razi University Kermanshah Iran;

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Resveratrol downregulates TGF-β1 and Smad3 expression and attenuates oxidative stress in CCl4-induced kidney damage in rats

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