Pharmacological basis for the medicinal use of Michelia champaca in gut,airways and cardiovascular disorders

Fatima Saqib; Zubia Mushtaq; Khalid Hussain Janbaz; Imran Imran; Saikat Deawnjee; Muhammad Zia-Ul-Haq; Lorena Dima

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Pharmacological basis for the medicinal use of Michelia champaca in gut,airways and cardiovascular disorders

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Objective: To discover the mechanism behind ameliorative effects of Michelia champaca (M. champaca) in gastrointestinal, respiratory and cardiovascular disorders. Methods: Anti-spasmodic potential was evaluated by trying the M. champaca extract (aqueous:ethanolic) on rabbit aorta, trachea and jejunum in vitro. Isotonic and isometric transducers coupled with Power Lab data acquisition system was used to record the responses of isolated tissues. Results: M. champaca extract relaxed the spontaneous and high K+(80 mmol/L)-induced contractions of isolated jejunum preparation of rabbit showing a Ca2+channel blocking mechanism. Moreover, extract shifted calcium concentration response curves towards right like standard calcium channel blocker verapamil. In rabbit tracheal preparation, M. champaca relaxed both carbachol (1 μmol/L) and high K+-induced contractions, likewise verapamil. In rabbit aorta preparation, M. champaca relaxed phenylephrine (1 μmol/L) and high K+-induced contractions similar to verapamil. Conclusion: M. champaca possesses spasmolytic, airways relaxant and vasodilator actions mediated perhaps due to blocking of Ca2+channels, hence validating its therapeutic usage in diarrhea, asthma and hypertension.

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《亚太热带医药杂志（英文版）》 |2018年第4期|292-296|共5页
作者
Fatima Saqib; Zubia Mushtaq; Khalid Hussain Janbaz; Imran Imran; Saikat Deawnjee; Muhammad Zia-Ul-Haq; Lorena Dima;
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Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan;

Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan;

Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan;

Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan;

Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India;

Office of Research, Innovation and Commercialization, Lahore College for Women University, Lahore 54600, Pakistan;

Faculty of Medicine, Transilvania University of Brasov, Romania;

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Pharmacological basis for the medicinal use of Michelia champaca in gut,airways and cardiovascular disorders

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