Association of glycosylated hemoglobin level with lipid ratio and individual lipids in type 2 diabetic patients

Zhe Yan; Yang Liu; Hui Huang

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Association of glycosylated hemoglobin level with lipid ratio and individual lipids in type 2 diabetic patients

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Objective:To study the correlation of lipid ratios and individual lipid indexes of patients with type2 diabetes with glycosylated hemoglobin (HbA1c).Methods:Samples were collected from 128 type2 diabetic patients (aged19-90 years; male 72, female56). The sera were analyzed for HbA1c, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). According to theHbA1c level, the patients were divided into three groups, groupA (HbA1c <7%,n=31), groupB (7%≤HbA1c≤10%,n=48), and groupC (HbA1c >10%,n=49). The correlation ofHbA1cwith lipid ratios & individual lipid indexes were analyzed.Results:With the increased level ofHbA1c,LDL-C had a significantly increasing trend (P<0.05); whereasTC went up with the increasedHbA1c, without any significant differences between three groups. There was no significant correlation betweenHbA1c andTG or HDL-C. With the increased level ofHbA1c,TC/HDL-C,LDL-C/HDL-C ratios were gradually increased, with significant differences among groups (P<0.05). The lipid ratios, especiallyLDL-C/HDL-C ratio was more susceptible to impaired lipid metabolism inT2DM patients than individual lipid. Conclusions:LDL-C/HDL-C ratio is helpful in assessing and reducing the risk of cardiovascular disease caused by impaired lipid metabolism in type2 diabetic patients.

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《亚太热带医药杂志（英文版）》 |2012年第006期|469-471|共3页
作者
Zhe Yan; Yang Liu; Hui Huang;
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Department of Endocrine and Metabolism, Sichuan University Westchina Hospital, Chengdu, Sichuan, China;

Department of Endocrine and Metabolism, Sichuan University Westchina Hospital, Chengdu, Sichuan, China;

Department of Endocrine and Metabolism, Sichuan University Westchina Hospital, Chengdu, Sichuan, China;

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Association of glycosylated hemoglobin level with lipid ratio and individual lipids in type 2 diabetic patients

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