Effects of histamine H1R-H4R-agonist on the airway epithelium of rabbits

Naushad A Dilkash; Trivendra Tripathi; Aijaz Ahmed Khan; Mohd Shahid; Haris M Khan; Mashiatullah Siddiqui; Rahat Ali Khan

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Effects of histamine H1R-H4R-agonist on the airway epithelium of rabbits

机译：组胺H1R-H4R激动剂对家兔气道上皮的影响

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Objective: To explore the exact role of histamine receptors in respiratory system. Methods:The cohort comprised of six groups (group I control and group II-VI treated) containing five rabbits in each group. Control-group received vehicle (sterile distilled water) and treated groups received subcutaneous histamine (100μg/kg, b.i.d.), and H1R-agonist (HTMT), H2R-agonist (amthamine), H3R-agonist (R-(-)-α-methylhistamine) and H4R-agonist (clobenpropit) each in a dose of 10μg/kg, b.i.d. for 30 subsequent days. After completion of treatment, animals were euthanized and perfused with 10%buffered formalin. Small tissue blocks of trachea and lungs were processed for paraffin embedding. Observations were recorded in sample photomicrographs taken from 10μm thick. Haematoxylin and eosin stained sections. Results:It was observed that trachea and bronchi from histamine, H1R and H4R groups had only patches of hyperplastic and hypertrophied epithelium and in general, cells in the affected region were taller heaped up. The bronchiolar epithelia from all treated groups showed hypertrophy and hyperplasia throughout with most of the cells having rounded profile and appeared to bud out from the basal cells. Conclusions:It is concluded that histamine receptors on induction via its specific agonist can induce hypertrophy, hyperplasia of respiratory tract epithelia suggesting its role akin to growth stimulating factor and warranting further long-term study.

机译：目的：探讨组胺受体在呼吸系统中的确切作用。方法：该队列由六组（I组对照组和II-VI组治疗）组成，每组五只兔子。对照组接受媒介物（无菌蒸馏水），治疗组接受皮下组胺（100μg/ kg，bid），H1R-激动剂（HTMT），H2R-激动剂（氨基胺），H3R-激动剂（R-（-）-α -甲基组胺）和H4R-激动剂（clobenpropit）各自的剂量为10μg/ kg，随后的30天。治疗完成后，对动物实施安乐死并用10％缓冲福尔马林灌注。气管和肺的小组织块被处理以进行石蜡包埋。观察结果记录在10微米厚的样品显微照片中。苏木精和曙红染色切片。结果：观察到，组胺，H1R和H4R组的气管和支气管只有增生和肥大的上皮斑块，总的来说，受影响区域的细胞堆积得更高。所有治疗组的细支气管上皮均显示肥大和增生，大多数细胞呈圆形，并从基底细胞萌芽。结论：结论：通过特异性激动剂诱导的组胺受体可以诱导肥大，呼吸道上皮增生，提示其与生长刺激因子相似，因此有必要进行长期的研究。

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《亚太热带医药杂志（英文版）》 |2010年第005期|367-370|共4页
作者
Naushad A Dilkash; Trivendra Tripathi; Aijaz Ahmed Khan; Mohd Shahid; Haris M Khan; Mashiatullah Siddiqui; Rahat Ali Khan;
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Department of Anatomy, Faculty of Medicine, Jawaharlal Nehru Medical College&Hospital, Aligarh Muslim University, Aligarh-202 002, India;

Department of Biochemistry, Faculty of Medicine, Jawaharlal Nehru Medical College&Hospital, Aligarh Muslim University, Aligarh-202 002, India;

Department of Anatomy, Faculty of Medicine, Jawaharlal Nehru Medical College&Hospital, Aligarh Muslim University, Aligarh-202 002, India;

Department of Microbiology, Faculty of Medicine, Jawaharlal Nehru Medical College&Hospital, Aligarh Muslim University, Aligarh-202 002, India;

Department of Microbiology, Faculty of Medicine, Jawaharlal Nehru Medical College&Hospital, Aligarh Muslim University, Aligarh-202 002, India;

Department of Biochemistry, Faculty of Medicine, Jawaharlal Nehru Medical College&Hospital, Aligarh Muslim University, Aligarh-202 002, India;

Department of Pharmacology, Faculty of Medicine, Jawaharlal Nehru Medical College&Hospital, Aligarh Muslim University, Aligarh-202 002, India;

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Effects of histamine H1R-H4R-agonist on the airway epithelium of rabbits

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