A survey on Hibiscus rosa-sinensis, Alcea rosea L. and Malva neglecta Wallr as antibacterial agents

Seyyed Mansour Seyyednejad; Haniyeh Koochak; Esmaeil Darabpour; Hossein Motamedi

摘要

Objective:To guide for selection of plants with antibacterial activity for further phytochemical works on the isolation and identification of the active compounds. Methods: Ethanolic extracts of 3 species from Malvaceae family were evaluated by agar disc diffusion method for antibacterial activity against some gram-positive and gram-negative bacteria (Pseudomonas aeruginosa, Listeria monocytogenes, Staphylococcus epidermidis, Staphylococcus aureus, Klebsiella pneumoniae, Salmonella typhi, Bacillus cereus, Bacillus anthracis, Escherichia coli and Streptococcus pyogenes). The extracts were obtained from aerial parts of Hibiscus rosa (H. rosa)-sinensis (leaf and flower), Alcea rosea (A. rosea) L. (leaf and flower) and Malva neglecta (M. neglecta) Wallr (flower). Results:These extracts had inhibitory effects at different concentrations (0.05, 0.10, 0.20 and 0.40 g/mL) against above mentioned bacteria. Escherichia coli was the most resistant strain. The highest inhibitory zone was showed by ethanolic extract of M. neglecta against Staphylococcus epidermidis (22 mm) and followed by ethanolic extract from flower of H. rosa against Staphylococcus epidermidis and Staphylococcus aureus (20 mm). The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) values against Staphylococcus epidermidis were equal (MIC=MBC=5 mg/mL for M. neglecta extract and for H. rosa extract MIC=MBC=20 mg/mL). Conclusions:These findings suggest that these native plants have good antibacterial properties that can be used for infection control and treatment and could also be as new source for antibiotics discovery and infection treatment.

机译：目的：指导具有抗菌活性的植物的筛选，以进一步进行植物的化学成分分离和鉴定。方法：采用琼脂圆盘扩散法评价了来自锦葵科的3种乙醇提取物对某些革兰氏阳性和革兰氏阴性细菌（铜绿假单胞菌，单核细胞增生李斯特菌，表皮葡萄球菌，金黄色葡萄球菌，肺炎克雷伯菌，鼠伤寒杆菌，沙门氏菌）的抗菌活性。蜡状芽孢杆菌，炭疽杆菌，大肠杆菌和化脓性链球菌）。提取物取自芙蓉（H. rosa）-中华（叶和花），蔷薇（Alcea rosea（A. rosea）L.（叶和花）和锦葵（M. neglecta）Wallr（花）的地上部分。结果：这些提取物在不同浓度（0.05、0.10、0.20和0.40 g / mL）下对上述细菌具有抑制作用。大肠杆菌是最耐药的菌株。最高的抑菌圈是由疏螺旋体的乙醇提取物对表皮葡萄球菌（22 mm），其次是罗莎螺旋体花的乙醇提取物对表皮葡萄球菌和金黄色葡萄球菌的乙醇提取。对表皮葡萄球菌的最小抑菌浓度（MIC）和最小杀菌浓度（MBC）值相等（对于疏叶支原体提取物和玫瑰蔷薇提取物MIC = MBC = 5 mg / mL，MIC = MBC = 20 mg / mL）。结论：这些发现表明这些天然植物具有良好的抗菌特性，可用于感染控制和治疗，也可作为抗生素发现和感染治疗的新来源。

A survey on Hibiscus rosa-sinensis, Alcea rosea L. and Malva neglecta Wallr as antibacterial agents

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