Prescription pattern of anti-malarial drugs in a tertiary care hospital

Santoshkumar R Jeevangi; Manjunath S; Sharanabasappa M Awanti

摘要

Objective:To evaluate the prescribing pattern of anti malarial drugs in a tertiary care hospital. Methods:A prospective cross-sectional study was conducted for 6 months of patients visiting in Basaveshwar Teaching and General Hospital, Gulbarga. Data were analyzed for various drug use indicators. Results: A total of 212 prescriptions were collected, with 136 (64.15%) male and 76 (35.85%) female. There were 128 (60.37%) Plasmodium vivax cases and 84 (39.63%) Plasmodium falciparum cases. All Plasmodium vivax cases were treated with chloroquine alone and among these 16 (12.5%) recieved radical treatment with primaquine along with chloroquine. Among 84 patients with Pasmodium falciparum, 40 patients received single drug such as quinine/mefloquinine/artesunate/arteether. Another 44 patients received multidrug regime like, quinine+artesunate (54.54%), quinine+mefloquine (27.27%) and quinine+arteether (18.18%). Chloroquine was not administered to any of the patients with Plasmodium falciparum malaria. The most common adverse effects with chloroquine were anorexia, nausea, vomiting and tinnitus in 9.37%of the cases. With quinine it was nausea and vomiting in 17.64%, tinnitus in 11.76%and hypoglycemia in 2.1%of cases. Conclusions: Our study found the perennial favorites like chloroquine for Plasmodium vivax and quinine for Plasmodium falciparum were the most effective drug. In the severe Plasmodium falciparum cases the artesunate derivatives and combination of artesunate with quinine/mefloquine were most effective with fewer incidences of side effects.

机译：目的：评估三级医院抗疟药物的处方方式。方法：对在Gulbarga的Basaveshwar教学和综合医院就诊的6个月患者进行了前瞻性横断面研究。分析了各种药物使用指标的数据。结果：共收集了212张处方，男性136张（64.15％），女性76张（35.85％）。间日疟原虫病例128例（60.37％），恶性疟原虫病例84例（39.63％）。所有间日疟原虫病例均单独接受氯喹治疗，其中16例（12.5％）接受了伯氨喹和氯喹的根治性治疗。在84例恶性疟原虫患者中，有40例患者接受了奎宁/甲氟奎宁/青蒿琥酯/蒿甲醚等单一药物治疗。另外44例患者接受了多种药物治疗，如奎宁+青蒿琥酯（54.54％），奎宁+甲氟喹（27.27％）和奎宁+青蒿醚（18.18％）。未对任何恶性疟原虫疟疾患者使用氯喹。氯喹最常见的不良反应是厌食，恶心，呕吐和耳鸣，占9.37％。奎宁引起恶心呕吐的占17.64％，耳鸣占11.76％，低血糖症占2.1％。结论：我们的研究发现，常年使用的最有效的药物如间日疟原虫的氯喹和恶性疟原虫的奎宁。在严重的恶性疟原虫病例中，青蒿琥酯衍生物以及青蒿琥酯与奎宁/甲喹的组合最有效，且副作用发生率较低。

Prescription pattern of anti-malarial drugs in a tertiary care hospital

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