Objective:To investigate the gastroprotective activity of hydroalcoholic extract leaves ofFicus religiosa(F. religiosa) in different experimental models of gastric ulcer in rats.Methods: The hydroalcoholic extract leaves ofF. religiosa were studied at two dose levels (250 and500 mg/kg, oral) in rats against absolute ethanol (0.2 mL oral), aspirin (200 mg/kg) and pyloric ligation induced gastric ulcer. Ranitidine (50mg/kg, oral) was used as a standard drug. Mean ulcer indices and oxidative stress were measured. Phytochemical tests and acute toxicity tests were also carried out.Results:Administration ofF. religiosa to rats significantly decreased the ulcer index value when compared with the control treated group. Ranitidine (50 mg/kg, oral) also produced a significant decrease the ulcer index value when compared with the control treated group. Phytochemical analysis revealed the presence of tannins, sterols, saponins, flavonoids, carbohydrates and proteins.Conclusions: The results suggest that the leaves of theF. religiosa possess significant anti ulcer activity.
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