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首页> 中文期刊> 《亚太热带医药杂志（英文版）》 >Anti-schistosomal activities of Echinops kebericho Mesfin root and Hagenia abyssinica (Bruce) J.F Gmel flower part crude extracts in Swiss albino mice

Anti-schistosomal activities of Echinops kebericho Mesfin root and Hagenia abyssinica (Bruce) J.F Gmel flower part crude extracts in Swiss albino mice

         
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摘要

Objective: To evaluate the in vivo antischistosomal activities of the crude extracts of Echinops kebericho Mesfin (E. kebericho) root and Hagenia abyssinica (Bruce) J.F. Gmel (H. abyssinica) flower. Methods: Mice were infected with (150 ± 10) Schistosoma mansoni cercariae by paddling technique. Crude extracts were administered orally for five consecutive days at doses of 300, 600 and 1200 mg/kg/day along with 200 mg/kg/day praziquantel and 3％ tween 80 given as a control. Results: E. kebericho root extract showed a statistically significant (P <0.05) reduction in fecal egg count of 64.44％, 42.96％ ﹠ 26.82％ and worm burden of 65.71％, 47.86％ ﹠ 31.43％ at treatment doses of 1200 mg/kg/day, 600 mg/kg/day and 300 mg/kg/day, respectively. Similarly, H. abyssinica flower extracts showed a significant (P < 0.05) reduction in fecal egg count up to 84.57％, 77.06％ ﹠ 63.89％ and worm burden of 91.43％, 81.43％﹠ 70.71％ at a respective dose levels. In addition, a significant (P < 0.05) reduction in liver granuloma score was observed in all H. abyssinica administered dose groups and E. kebericho at 1200 mg/kg/day dose group as compared to infected untreated control group. Conclusions: H. abyssinica and E. kebericho crude extracts show a promising antischistosomal activity.

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  • 来源
    《亚太热带医药杂志（英文版）》 |2018年第10期|570-575|共6页
  • 作者

    Yonas Alemu; Zeleke Mekonnen; Ahmed Zeynudin; Moti Yohannes; Abdissa Biruksew; Sultan Suleman;

  • 作者单位

    School of Medical Laboratory Sciences;

    Jimma University;

    P.O. Box: 378;

    Jimma;

    Ethiopia;

    School of Medical Laboratory Sciences;

    Jimma University;

    P.O. Box: 378;

    Jimma;

    Ethiopia;

    School of Medical Laboratory Sciences;

    Jimma University;

    P.O. Box: 378;

    Jimma;

    Ethiopia;

    School of Veterinary Medicine;

    Jimma University;

    P.O. Box: 378;

    Jimma;

    Ethiopia;

    School of Medical Laboratory Sciences;

    Jimma University;

    P.O. Box: 378;

    Jimma;

    Ethiopia;

    School of Pharmacy;

    Jimma University;

    P.O. Box: 378;

    Jimma;

    Ethiopia;

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  • 正文语种 eng
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