STEREOSELECTIVE TOTAL SYNTHESIS OF CHRYSANTHEMOL

LI-YUAN MOU; LI-YA ZHU; ZI-YUN LIN; XIA-OTIAN LIANG

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STEREOSELECTIVE TOTAL SYNTHESIS OF CHRYSANTHEMOL

机译：菊花醇的立体选择性全合成

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Chrysanthemol (1), a trans-eudesmane type sesquiterpene from Chrysanthemum indicum L.,possesses certain anti-inflammatory activity. Its total synthesis was approached from two alternative routes and finally accomplished in ten steps from R-(+)-carvone via α-eudesmol (10) as the key intermediate. The overall yield is 2.4% and the spectral data of the synthetic target compound were identical with that of natural chrysanthemol (1). Seven intermediary compounds were tested for inhibitory effects on the carragenan-induced swelling of mouse paw but demonstrated no obvious activities.

机译：菊花（1）是一种来自菊科植物的反欧德香型倍半萜烯，具有一定的抗炎活性。它的总合成是通过两种替代途径进行的，最终通过R-（+）-香芹酮以α-eudesmol（10）作为关键中间体，从十个步骤完成。总产率为2.4％，合成目标化合物的光谱数据与天然菊花（1）相同。测试了七个中间化合物对角叉菜胶诱导的小鼠爪肿胀的抑制作用，但没有明显的活性。

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来源
《亚洲天然物产研究（英文版）》 |2001年第2期|103-116|共14页
作者
LI-YUAN MOU; LI-YA ZHU; ZI-YUN LIN; XIA-OTIAN LIANG;
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作者单位

Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;

Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;

Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;

Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;

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原文格式 PDF
正文语种 chi
中图分类植物学;
关键词
Chrysanthemol (1); Total synthesis; Anti-inflammatory activity;

机译：菊花（1）;全合成;抗炎活性;

STEREOSELECTIVE TOTAL SYNTHESIS OF CHRYSANTHEMOL

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