Flavonoid chemical composition and antidiabetic potential of Brachychiton acerifolius leaves extract

Aisha Hussein Abou Zeid; Mohamed Ali Farag; Manal Abdel Aziz Hamed; Zeinab Abdel Aziz Kandil; Radwa Hassan El-Akad; Hanaa Mohamed El-Rafie

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Flavonoid chemical composition and antidiabetic potential of Brachychiton acerifolius leaves extract

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Objective:To evaluate Brachychiton acerifolius leaf extracts as antidiabetic potential agent and to identify the main active constituents using bioactivity guided fractionation.Methods:In vitro antioxidant activity was evaluated for B.acerifolius different extracts using DPPH assay and vitamin C as control.Antidiabetic activity was then determined using STZ-induced rats treated daily with ethyl acetate and 70% ethanol leaf extracts for4 weeks at a dose of 200 g/kg body weight against gliclazide reference drug.Blood glucose,a-amylase,lipid profile,liver function enzymes and oxidative stress markers were assessed along with histopathological study for liver and pancreatic tissues.Isolation and structural elucidation of active compounds were made using Diaion and Sephadex followed by spectral analyses.Results:The results indicated that ethyl acetate and ethanol leaf extracts exhibited the strongest antioxidant activity compared to that of vitamin C(IC500.05,0.03 and 12 mg/m L,respectively).Both extracts showed potent anti-hyperglycemic activity evidenced by a significant decrease in serum glucose levels by 82.5% and 80.9% and a-amylase by45.2% and 53.6%,as compared with gliclazide 68% and 59.4%,respectively.Fractionation of ethanol extract resulted in the isolation of 9 flavonoids including apigenin-7-O-arhamnosyl(1/2)-b-D-glucuronide,apigenin-7-O-b-D-glucuronide,apigenin-7-O-b-Dglucoside and luteolin-7-O-b-D-glucuronide.Conclusions:This study highlights the potential use of B.acerifolius leaf extract enriched in flavones for the treatment of diabetes that would warrant further clinical trials investigation.

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《亚太热带生物医学杂志：英文版》 |2017年第005期|P.389-396|共8页
作者
Aisha Hussein Abou Zeid; Mohamed Ali Farag; Manal Abdel Aziz Hamed; Zeinab Abdel Aziz Kandil; Radwa Hassan El-Akad; Hanaa Mohamed El-Rafie;
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Pharmacognosy Department,National Research Centre;

Pharmacognosy Department,College of Pharmacy,Cairo University;

Therapeutic Chemistry Department,National Research Centre;

Pharmacognosy Department,National Research Centre;

Pharmacognosy Department,College of Pharmacy,Cairo University;

Therapeutic Chemistry Department,National Research Centre;

Pharmacognosy Department,National Research Centre;

Pharmacognosy Department,College of Pharmacy,Cairo University;

Therapeutic Chemistry Department,National Research Centre;

Pharmacognosy Department,National Research Centre;

Pharmacognosy Department,College of Pharmacy,Cairo University;

Therapeutic Chemistry Department,National Research Centre;

Pharmacognosy Department,National Research Centre;

Pharmacognosy Department,College of Pharmacy,Cairo University;

Therapeutic Chemistry Department,National Research Centre;

Pharmacognosy Department,National Research Centre;

Pharmacognosy Department,College of Pharmacy,Cairo University;

Therapeutic Chemistry Department,National Research Centre;

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正文语种 CHI
中图分类中药化学;
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Flavonoid chemical composition and antidiabetic potential of Brachychiton acerifolius leaves extract

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