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首页> 中文期刊> 《亚太热带生物医学杂志：英文版》 >Potential bioactive phytochemicals, antioxidant properties and anticancer pathways of Nymphaea nouchali

Potential bioactive phytochemicals, antioxidant properties and anticancer pathways of Nymphaea nouchali

         
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摘要

Objective:To investigate bioactive phytochemicals and antioxidant activities of Nymphaea nouchali and to explore its anticancer pathways by a network pharmacology approach.Methods:Using a spectrophotometer and high-performance liquid chromatography-diode array detector(HPLC-DAD),we quantified bioactive phytochemicals in methanolic extract of Nymphaea nouchali tuber.The extracts were investigated for in vitro antioxidant properties.Targets of these bioactive phytochemicals were predicted and anticancer-associated pathways were analyzed by a network pharmacology approach.Moreover,we identified the predicted genes associated with cancer pathways and the hub genes in the protein-protein interaction network of predicted genes.Results:Quantitative results indicated the total phenolics,total flavonoids,and total proanthocyanidins in the methanolic extract of Nymphaea nouchali tuber.HPLC-DAD analysis showed rutin(39.44 mg),catechin(39.20 mg),myricetin(30.77 mg),ellagic acid(11.05 mg),gallic acid(3.67 mg),vanillic acid(0.75 mg),rosmarinic acid(4.81 mg),p-coumaric acid(3.35 mg),and quercetin(0.90 mg)in 1 g of dry extract.The extract showed the radical scavenging activities of 2,2-diphenyl-1-picrylhydrazyl,2,2’-azinobis(3-ethylbenzothiazoline-6-sulfonic acid)and N,N-dimethyl-pphenylenediamine.By using network pharmacology,we predicted 130 target genes associated with cancer pathways.The top hub genes(IL6,AKT1,EGFR,JUN,PTGS2,MAPK3,CASP3,and CXCL8)were also identified,which were associated with cancer pathways and interacted with bioactive phytochemicals of the methanolic extract of Nymphaea nouchali tuber.Conclusions:Our study provides insights into the mechanism of anticancer activities of the methanolic extract of Nymphaea nouchali tuber.

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  • 来源
    《亚太热带生物医学杂志：英文版》 |2020年第12期|P.555-562|共8页
  • 作者

    Md.Nazim Uddin; Md.Abdus Samad; Md.Abu Zubair; Md.Zahurul Haque; Kanika Mitra; Tanzir Ahmed Khan; Md.Amir Hossain; Ashikujaman Syed; Aklima Afroze;

  • 作者单位

    Institute of Food Science and Technology Bangladesh Council of Scientific and Industrial Research Dhaka 1205 BangladeshSchool of Basic Medicine and Clinical Pharmacy China Pharmaceutical University Nanjing Jiangsu 211198 China;

    Department of Food Technology and Nutritional Science Mawlana Bhashani Science and Technology University Santosh Tangail 1902 Bangladesh;

    Department of Food Technology and Nutritional Science Mawlana Bhashani Science and Technology University Santosh Tangail 1902 Bangladesh;

    Institute of Food Science and Technology Bangladesh Council of Scientific and Industrial Research Dhaka 1205 Bangladesh;

    Institute of Food Science and Technology Bangladesh Council of Scientific and Industrial Research Dhaka 1205 Bangladesh;

    Institute of Food Science and Technology Bangladesh Council of Scientific and Industrial Research Dhaka 1205 Bangladesh;

    Center for New Drug Safety Evaluation and Research China Pharmaceutical University Jiangsu Nanjing 211198 China;

    School of Pharmacy Lanzhou University Lanzhou 730000 China;

    School of Pharmacy China Pharmaceutical University Nanjing Jiangsu 211198 China;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 中药化学;
  • 关键词

    Bioactive phytochemicals; Anticancer pathways; Malignancy; Network pharmacology; Nymphaea nouchali;

    机译：生物活性植物化学物质;抗癌途径;恶性;网络药理学;睡莲;
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