Syringic acid induces cancer cell death in the presence of Cu(Ⅱ)ions via pro-oxidant activity

Marzieh Rashedinia; Azita Nasrollahi; Marzieh Shafaghat; Shahrzad Momeni; Forough Iranpak; Jamileh Saberzadeh; Rita Arabsolghar; Zahra Sabahi

首页> 中文期刊> 《亚太热带生物医学杂志：英文版》 >Syringic acid induces cancer cell death in the presence of Cu(Ⅱ)ions via pro-oxidant activity

Syringic acid induces cancer cell death in the presence of Cu(Ⅱ)ions via pro-oxidant activity

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Objective:To investigate the effects of syringic acid on HEK 293 and HepG2 cells in the absence and presence of exogenous Cu(Ⅱ)and Fe(Ⅱ)ions.Methods:The antiproliferative effects of syringic acid on HEK 293 and HepG2 cells in the absence and presence of exogenous Cu(Ⅱ)and Fe(Ⅱ)ions were examined by MTT assay.Additionally,colony-forming,reactive oxidative species(ROS)generation,apoptosis induction,autophagy,mitochondrial membrane potential,and mitochondrial mass were investigated.Results:At 24 and 72 h,no significant differences were observed in the viability of HepG2 cells between the control and syringic acid+Fe(Ⅱ)groups.However,exposure of HepG2 cells to syringic acid+Cu(Ⅱ)for 72 h reduced the cell viability significantly.Furthermore,ROS formation,induction of apoptosis,and autophagic vacuoles were significantly increased in HepG2 cells without marked changes in mitochondrial membrane potential and mitochondrial mass.Moreover,syringic acid+Cu(Ⅱ)reduced the plating efficiency and surviving fraction significantly.Conclusions:The combination of syringic acid with Cu(Ⅱ)was toxic to cancer cells and showed pro-oxidant activity.In addition,this combination induced autophagy in cancer cells with less cytotoxic effects on normal cells,which is a potential candidate for the development of novel therapeutics towards cancer.

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《亚太热带生物医学杂志：英文版》 |2022年第6期|270-278|共9页
作者
Marzieh Rashedinia; Azita Nasrollahi; Marzieh Shafaghat; Shahrzad Momeni; Forough Iranpak; Jamileh Saberzadeh; Rita Arabsolghar; Zahra Sabahi;
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作者单位

Medicinal Plants Processing Research Center University of Medical Sciences;

Department of Pharmacology and Toxicology of Pharmacy University of Medical Sciences;

Diagnostic Laboratory Sciences and Technology Research Center of Paramedical Sciences University of Medical Sciences;

Department of Biochemistry Azad University of Shiraz;

Department of Medical Laboratory Sciences of Paramedical Sciences University of Medical Sciences;

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原文格式 PDF
正文语种 chi
中图分类肿瘤学;
关键词
Syringic acid; Copper; IRON; Cancer cell; PRO-OXIDANT; AUTOPHAGY;

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Syringic acid induces cancer cell death in the presence of Cu(Ⅱ)ions via pro-oxidant activity

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