目的 大鼠心电信号采集目前依赖于生理信号采集系统,其采样频率低,且无法进行软件算法的内部改造,不利于实验使用.本文设计了高精度大鼠心电信号采集系统以实现RR间期实时检测.方法 采用AD620设计心电信号采集电路,信号经USB-6008进行A/D转换后送入PC机,通过Labview编程完成滤波、预处理及显示.然后,通过Labview与Matlab混合编程,采用模板匹配方法实现RR间期实时检测.最后,随机选取10只大鼠心电数据进行离线分析,以阈值法作为对照检验RR间期实时检测的准确性.结果 阈值法检出率96.62%,模板匹配法检出率99.16%.结论 通过硬件与软件结合的方法能够获得高精度的大鼠心电信号.通过Labview与Matlab混合编程,采用模板匹配法能够实现RR间期实时检测,且检测准确性较高,为进一步的实验研究提供了基础.%Objective The rat ECG acquisition bases on various physiological signal acquisition systems at present. The users can not modify the analysis algorithm inside and these systems with low sampling frequencies are not useful. This article introduces a high-accuracy rat ECG acquisition system which realizes realtime detection of RR intervals. Methods First, we designed an ECG acquisition circuit based on AD620. USB-6008 was used to realize A/D conversion. Then the real-time detection of RR intervals was realized by Labview combined with Matlab by means of template matching method. Finally, to checkout the accuracy of the real-time detection of RR intervals, ECG signals of 10 randomly selected rats were analyzed offline compared with the threshold method. Results The detection rate of the threshold method and the template matching method were 96. 62% and 99. 16% , respectively. Conclusions High-accuracy rat ECG acquisition system can be realized by means of software combined with hardware. The real-time detection of RR intervals realized by Labview combined with Matlab by means of template matching method is accurate and provides the basis of the rat ECG research.
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