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首页> 中文期刊> 《生物医学与环境科学：英文版》 >Effects of Cigarette Smoking and Smoking Cessation on Plasma Constituents and Enzyme Activities Related to Oxidative Stress

Effects of Cigarette Smoking and Smoking Cessation on Plasma Constituents and Enzyme Activities Related to Oxidative Stress

         
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摘要

In order to study effects of cigarette smoking and smoking cessation on plasma constituents and enzyme activities related to oxidative stress, 1255 smokers and 524 healthy non_smokers were investigated in terms of plasma levels of lipoperoxides (LPO), nitric oxide (NO), vitamin C (VC), vitamin E (VE) and β carotene (β CAR). Additionally, erythrocytes were examined to deterimine the level of LPO, the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH_Px). The results showed that, when compared with the average values of the non_smoker group, the average plasma values of LPO, NO and the average erythrocyte value of LPO in the smoker group were significantly increased ( P 0.05). This finding indicates that the markedly increased oxidative stress in smokers might gradually return to normal but only after a long period of smoking cessation. In conclusion, in the bodies of smokers a series of free radical chain reactions were gravely aggravated, the dynamic balance between oxidation and antioxidation was seriously disrupted, and oxidative stress was clearly exacerbated, which is closely related to many disorders or diseases in smokers. The present study underscored the need, urgency and importance of complete smoking cessation.

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