The effect of Pb2+ on 3H-DL-Glutamate （3H-DL-Glu） binding in the membrane preparations from the hippocampus of rat brain was investigated with a view to explaining the cognitive and learning deficits produced by the heavy metal. The results indicated that Pb2+ （3. 1-25. 0 μmol.L -1 ） inhibited 3 H-DL-Glu binding in a concentration-dependent manner . Scatchard analysis further revealed that at a concentration of 6. 3 μmol.L-1 Pb2 + interfered with binding mainly through significantly decreasing the density of binding sites. This finding provided an important insight into Pb2+ -induced impairments in learning and memory previously documented in children and in experimental animals chronically exposed to
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机译：Purified Suilysin Secreted by Streptococcus suis Serotype 2 Induce Interleukin-6 by Rat Brain Microvascular Endothelial CellsAU Guo, Yang Yi, Pengfei Zhang, Tao Zhu, Xinyi Hu, Ge Dong, Hong Jiang, Daixun Duan, Huiqin Wang, Jianfang Mu, Xiang (muxiang1109@sina.com) Wei, Xubin (619034228@qq.com)
