DHA Depletion in Rat Brain Is Associated With Impairment on Spatial Learning and Memory

YING XIAO; LING WANG; RUO-JUN XU; ZHEN-YU CHEN

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DHA Depletion in Rat Brain Is Associated With Impairment on Spatial Learning and Memory

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To examine the effect of docosahexaenoic acid (DHA) deficiency in brain on spatial learning and memory in rats. Methods Sprague Dawley rats were fed with an n-3 fatty acid deficient diet for two generations to induce DHA depletion in brain. DHA in seven brain regions was analyzed using the gas-liquid chromatography. Morris water maze (MWM) was employed as an assessing index of spatial learning and memory in the n-3 fatty acid deficient adult rats of second generation. Results Feeding an n-3 deficient diet for two generations depleted DHA differently by 39%-63% in the seven brain regions including cerebellum, medulla, hypothalamus, stnatum, hippocampus, cortex and midbrain. The MWM test showed that the n-3 deficient rats took a longer time and swam a longer distance to find the escape platform than the n-3 Adq group. Conclusion The spatial learning and memory in adult rats are partially impaired by brain DHA depletion.

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《生物医学与环境科学：英文版》 |2006年第6期|474-480|共7页
作者
YING XIAO; LING WANG; RUO-JUN XU; ZHEN-YU CHEN;
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作者单位

Food and Nutrition Sciences Programme;

Department of Biochemistry;

The Chinese University of Hong Kong;

Shatin;

NT;

Hong Kong;

China;

Department of Nutrition and Food Hygiene;

School of Public Health;

Peking University Health Science Center;

Beijing;

China;

Food and Nutrition Division;

Department of Zoology;

The University of Hong Kong;

Hong Kong;

China;

Department of Nutrition and Food Hygiene;

College of Public Health;

Zhengzhou University;

China;

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原文格式 PDF
正文语种 chi
中图分类中枢神经系统生理学;
关键词
记忆; 大脑; 小脑; 下丘脑; 海马; 神经生理学; 骨髓;

机译：二十二碳六烯酸;记忆;莫里斯水迷宫;空间学习;

DHA Depletion in Rat Brain Is Associated With Impairment on Spatial Learning and Memory

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