Gene Expression Profile of Human Skeletal Muscle and Adipose Tissue of Chinese Han Patients with Type 2 Diabetes Mellitus

YAN-LI YANG; RUO-LAN XIANG; CHANG YANG; XIAO-JUN LIU; WEN-JUN SHEN; JIN ZUO; YONG-SHENG CHANG; Fu-DE FANG

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Gene Expression Profile of Human Skeletal Muscle and Adipose Tissue of Chinese Han Patients with Type 2 Diabetes Mellitus

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摘要

Objective To study the differential patterns of gene expression in skeletal muscle and adipose tissue between type 2 diabetes mellitus (T2DM) patients and healthy subjects using DNA microarray analysis. Methods T2DM patiens were divided into female group, young male group and old male group. DNA microarray analysis and quantitative real-time PCR were carried out to analyze the relation between gene expressions and T2DM. Results The mRNA expression of 298, 578, and 350 genes was changed in the skeletal muscle of diabetes mellitus patients compared with control subjects. The 1320, 1143, and 2847 genes were modified in adipose tissue of the three groups. Among the genes surveyed, the change of 25 and 39 gene transcripts in skeletal muscle and adipose tissue was ≥2 folds. These differentially expressed genes were classified into 15 categories according to their functions. Conclusion New genes are found and T2DM can be prevented or cured.

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《生物医学与环境科学：英文版》 |2009年第5期|359-368|共10页
作者
YAN-LI YANG; RUO-LAN XIANG; CHANG YANG; XIAO-JUN LIU; WEN-JUN SHEN; JIN ZUO; YONG-SHENG CHANG; Fu-DE FANG;
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作者单位

Department of Internal Medicine;

Peking Union Medical College Hospital;

Peking Union Medical College & Chinese Academy of Medical Sciences;

Beijing 100730;

China;

Department of Physiology and Pathophysiology;

Peking University Health ScienceCenter;

BeiJing 100083;

China;

National Laboratory of Medical Molecular Biology;

Institute of Basic Medical Sciences;

Peking Union Medical College & Chinese Academy of Medical Sciences;

Beijing 100005;

China;

Division of Endocrinology;

Stanford University and VA Palo Alto Health Care System;

3801 Miranda Avenue;

Palo Alto;

CA 94304;

USA;

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原文格式 PDF
正文语种 chi
中图分类分子遗传学;基因的表达;
关键词
2型糖尿病; 基因表达谱; 脂肪组织; 骨骼肌; DNA芯片; 汉族; mRNA表达; 差异表达基因;

机译：2型糖尿病;基因表达谱;脂肪组织;骨骼肌;DNA芯片;汉族;mRNA表达;差异表达基因;

Gene Expression Profile of Human Skeletal Muscle and Adipose Tissue of Chinese Han Patients with Type 2 Diabetes Mellitus

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