With regard to brain acetylcholinesterase and acetylcholine and serum triiodothyronine（T3）and thyroxine（T4）profiles,a biphasic response pattern was elicited in Channa punctatus chroni-cally exposed to nonlethal doses of locally used pesticides,namely,Metacid-50 and Carbaryl.Data revealed that these xenobiotics caused significant inhibition of brain acetylcholinesteraseactivity and a decrease in thyroxine level accompanied by a concurrent increase in acetylcholineaccumulation and T3 level.It is surmised that Metacid-50 and Carbaryl influence both neuraland hormonal functions.1989 Academic Press.Inc.
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