Human rotavirusesHRV are the major cause of diarrhea in infants and young children in the autumn and winter. In this papers many kinds of rotavirus vaccine are reviewed including live replicating attenuated rotaviruses subunit vaccine DNA vaccine synthesized peptides vaccine and so on. And many antigens of rotavirus are discribed such as VP7 VP4 VP6 and NSP4. Particular consideration is given to the prospects of the transgenic plant-derived rotavirus vaccine.%轮状病毒是目前婴幼儿秋冬季腹泻的最主要病原物。作者通过对轮状病毒减毒株疫苗、亚单位疫苗和DNA疫苗研究进展的综合分析,指出了减毒株疫苗在实际应用中存在的弊端,论述了开发新型轮状病毒疫苗,特别是转基因植物疫苗的必要性和可行性。
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