首页> 中文期刊> 《骨研究:英文》 >Two-year clinical outcome of denosumab treatment alone and in combination with teriparatide in Japanese treatment-naive postmenopausal osteoporotic women

Two-year clinical outcome of denosumab treatment alone and in combination with teriparatide in Japanese treatment-naive postmenopausal osteoporotic women

         

摘要

This randomized prospective study aimed to evaluate the clinical outcome of denosumab treatment alone and in combination with teriparatide in treatment-naive postmenopausal Japanese female patients with osteoporosis. Thirty patients were randomly assigned to two groups: (1) denosumab group (denosumab alone, n=13); and (2) combination group (denosumab+teriparatide, n=17). Serum bone-specific alkaline phosphatase (BAP), serum tartrate-resistant acid phosphatase (TRACP)-5b, urinary cross-linked N-terminal telopeptides of type I collagen (NTX), and bone mineral density (BMD) of L1–4 lumbar vertebrae (L-BMD) and bilateral total hips (H-BMD) were determined at the first visit and at various time points up to 24 months post-treatment to determine percentage changes.

著录项

  • 来源
    《骨研究:英文》 |2017年第002期|P.152-158|共7页
  • 作者单位

    [1]Department of Orthopedic Surgery, Shinshu University School of Medicine, Matsumoto, Japan;

    [2]Department of Orthopedic Surgery, Showa-Inan General Hospital, Komagane, Japan;

    [1]Department of Orthopedic Surgery, Shinshu University School of Medicine, Matsumoto, Japan;

    [3]Center of Osteoporosis and Spinal Disorders, Kamimura Orthopaedic Clinic, Matsumoto, Japan and;

    [1]Department of Orthopedic Surgery, Shinshu University School of Medicine, Matsumoto, Japan;

    [1]Department of Orthopedic Surgery, Shinshu University School of Medicine, Matsumoto, Japan;

    [1]Department of Orthopedic Surgery, Shinshu University School of Medicine, Matsumoto, Japan;

    [4]Department of Oral and Maxillofacial Radiology, Matsumoto Dental University, Shiojiri, Japan;

    [1]Department of Orthopedic Surgery, Shinshu University School of Medicine, Matsumoto, Japan;

  • 原文格式 PDF
  • 正文语种 CHI
  • 中图分类 医药、卫生;
  • 关键词

    teriparatide; denosumab; treatment;

    机译:特立帕肽;地诺单抗;治疗;
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