Understanding the function and dysfunction of the immune system in lung cancer： the role of immune checkpoints

Niki Karachaliou; Maria Gonzalez Cao; Cristina Teixido; Santiago Viteri; Daniela Morales-Espinosa; Mariacarmela Santarpia; Rafael Rosell1; 2; 4; 5; 6

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Understanding the function and dysfunction of the immune system in lung cancer： the role of immune checkpoints

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cqvip:Survival rates for metastatic lung cancer, including non-small cell lung cancer(NSCLC) and small cell lung cancer(SCLC), are poor with 5-year survivals of less than 5%. The immune system has an intricate and complex relationship with tumorigenesis; a groundswell of research on the immune system is leading to greater understanding of how cancer progresses and presenting new ways to halt disease progress. Due to the extraordinary power of the immune system—with its capacity for memory, exquisite specificity and central and universal role in human biology—immunotherapy has the potential to achieve complete, long-lasting remissions and cures, with few side effects for any cancer patient, regardless of cancer type. As a result, a range of cancer therapies are under development that work by turning our own immune cells against tumors. However deeper understanding of the complexity of immunomodulation by tumors is key to the development of effective immunotherapies, especially in lung cancer.

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《癌症生物学与医学：英文版》 |2015年第2期|P.79-86|共8页
作者
Niki Karachaliou; Maria Gonzalez Cao; Cristina Teixido; Santiago Viteri; Daniela Morales-Espinosa; Mariacarmela Santarpia; Rafael Rosell1; 2; 4; 5; 6;
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作者单位

[1]Instituto Oncologico Dr Rosell;

Quiron Dexeus University Hospital;

Barcelona 08028;

Spain;

[2]Pangaea Biotech;

Barcelona 08028;

Spain;

[3]Medical Oncology Unit;

Human Pathology Department;

University of Messina;

Messina 98122;

Italy;

[4]Catalan In- stitute of Oncology;

Hospital Germans Trias i Pujol;

Badalona 08916;

Spain;

[5]Molecular Oncology Research （MORe） Foundation;

Barcelona 08028;

Spain;

[6]Germans Trias i Pujol Health Sciences Institute and Hospital;

Campus Can Ruti 08916;

Spain;

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原文格式 PDF
正文语种 CHI
中图分类 S852.43;
关键词
非小细胞肺癌; 免疫系统; 检查点; 癌症患者; 肿瘤发生; 免疫治疗; 人类生物学; 癌症治疗;

机译：非小细胞肺癌;免疫系统;检查点;癌症患者;肿瘤发生;免疫治疗;人类生物学;癌症治疗;

Understanding the function and dysfunction of the immune system in lung cancer： the role of immune checkpoints

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