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首页> 中文期刊> 《心血管创新与应用》 >Relation between Cardiac Injury and Elevated Levels of Inflammatory Biomarkers in Patients with Severe COVID-19

Relation between Cardiac Injury and Elevated Levels of Inflammatory Biomarkers in Patients with Severe COVID-19

         
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摘要

Background:Since early December 2019,coronavirus disease 2019(COVID-19)has emerged as a global pandemic and public health crisis.This study aims to explore the relationship between cardiac injury and infl ammatory biomarkers in patients with severe COVID-19.Methods:We collected data on 91 patients with a confi rmed diagnosis of severe COVID-19 from February 8 to March 31,2020.Demographic characteristics,clinical data,and in-hospital outcomes were compared.The relationship between cardiac injury and infl ammatory biomarkers was analyzed.Logistic regression was used to explore the independent risk factors for cardiac injury.Results:The mean age of all patients was 61 years±14 years.About half of the patients were male.Hypertension and coronary heart disease were more common in the cardiac injury group.The levels of infl ammatory biomarkers in patients who experienced cardiac injury were generally higher than the levels of those without cardiac injury,including interleukin-6,interleukin-2 receptor(IL-2R),procalcitonin,and high-sensitivity C-reactive protein.There were positive correlations between the levels of high-sensitivity troponin I and N-terminal prohormone of brain natriuretic peptide and the levels of infl ammatory biomarkers.Logistic regression shows that IL-2R(odds ratio 1.001,95%confi dence interval 1.000–1.002,P=0.045)and comorbidities(odds ratio 4.909,95%confi dence interval 1.231–19.579,P=0.024)are independent risk factors for cardiac injury in patients with severe COVID-19.Conclusion:High levels of infl ammatory biomarkers are associated with higher risk of cardiac injury in patients with severe COVID-19.IL-2R and comorbidities are predictors of cardiac injury.

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  • 来源
    《心血管创新与应用》 |2021年第1期|P.165-172|共8页
  • 作者

    Jing Li; Lijie Sun; Fang Wang; Bing Liu; Hui Li; Guodong Tang; Zhigang Chang; Aihua Liu; Chunyi Fu; You Lv; Jing Gao; Jing Li;

  • 作者单位

    Division of Cardiology Beijing Hospital 100730 Beijing China;

    Division of Cardiology Xuanwu Hospital Capital Medical University 100053 Beijing China;

    Division of Cardiology Xuanwu Hospital Capital Medical University 100053 Beijing China;

    Division of Cardiology Beijing Hospital 100730 Beijing China;

    Division of Cardiology Beijing Hospital 100730 Beijing China;

    Division of Cardiology Beijing Hospital 100730 Beijing China;

    Division of Intensive Care Unit Beijing Hospital 100730 Beijing China;

    Division of Rheumatology and Immunology Beijing Hospital 100730 Beijing China;

    Division of Emergency Beijing Hospital 100730 Beijing China;

    Division of Cardiology Beijing Hospital 100730 Beijing China;

    Division of Cardiology Xuanwu Hospital Capital Medical University 100053 Beijing China;

    Division of Cardiology Xuanwu Hospital Capital Medical University 100053 Beijing ChinaNational Clinical Research Center of Geriatric Disease Xuanwu Hospital 100053 Beijing China;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 心脏、血管（循环系）疾病;
  • 关键词

    Infl ammatory biomarker; cardiac injury; COVID-19; risk;

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