MicroRNAs (miRNAs) are a series of conserved,short,non-coding RNAs that modulate gene expression in a posttranscriptional manner,miRNAs are involved in almost every physiological and pathological process.Type 1 diabetes (T1D) is an autoimmune disease that is the result of selective destruction of pancreatic β-cells driven by the immune system,miRNAs are also important participants in T1D pathogenesis.Herein,we review the most recent data on the potential involvement of miRNAs in T1D.Specifically,we focus on two aspects:the roles of miRNAs in maintaining immune homeostasis and regulating β-cell survival and/or functions in T1D.We also discuss circulating miRNAs as potent biomarkers for the diagnosis and prediction of T1D and investigate potential therapeutic approaches for this disease.
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