以右旋糖酐(DEX)为芯、聚乙二醇-b-聚(L-丙交酯-co-ε-己内酯)(PELCL)为壳,采用同轴电纺技术制备DEX/PELCL超细纤维膜.在该电纺纤维内芯分别负载血管内皮生长因子(VEGF)和血小板衍生生长因子(PDGF-bb),并以此构建双层超细纤维膜人工血管支架.28 d的释放结果表明,VEGF和PDGF-bb 均表现出突释现象,含有肝素的VEGF样品释放量有所下降.大鼠腹主动脉移植实验结果表明,载有VEGF和PDGFbb的超细纤维膜可以用于构建双层人工血管.%Core/shell ultrafine fibers, with dextran(DEX) and poly(ethylene glycol)-b-poly(L-lactide-co-εcaprolactone) (PELCL) as the core and shell, respectively, were prepared by coaxial electrospinning.Double-layered ultraline fibrous tubes of the coaxial-electrospun DEX/PELCL fiberswere constructed for application as artificial blood vessel by loading vascular endothelial growth factor (VEGF) and platelet derived growth factor-bb( PDGF-bb), respectively in the fiber core. The in vitro releasing results of 28 d indicated that initial burst release occurred for both VEGF and PDGF-bb. The in vivo implantation in abdomen aorta of a rat model showed that the double-layered fibrous tubes loading VEGF and PDGF-bb could be potential used as artificial blood vessels.
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