本文以2-氨基吡啶和α-溴代苯乙酮类化合物为起始原料,开发了新型吡啶并咪唑类化合物的合成方法,产率都在90%以上.在该反应中,通过微波辅助的作用,仅需要20分钟,就能完成目标化合物的合成.同时该合成方法在克级规模的实验中也具有较好的应用,目标产物的收率为91%.%A small collection of imidazo[1,2-a]pyridine derivatives were synthesized via a facile procedure under microwave irradi-ation in excellent yields up to 90%. Under the optimized reaction conditions,the starting materials were smoothly converted to corre-sponding products in only 20 minutes. This method was one example of cyclization which was enlarged gram-scale with the yield of 91%.
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