以浓硫酸为催化剂,利用粘卤酸和醇(或酚)在甲苯中回流,经脱水醚化反应合成了6个新的5-取代-3,4-二卤-2(5H)-呋喃酮化合物,产率在43～89％之间.化合物不同产率之间的差别可能与其醚化机理相关.新化合物的结构经1 H NMR、13 C NMR、EI-MS、IR、UV和元素分析等表征.这些具有不同生物活性基团化合物的设计与合成,为新型的2(5H)-呋喃酮衍生物的合成、活性测试及其进一步作为中间体的使用,以及由不同羟基化合物合成混合醚类化合物提供了参考.%Six new 5-substituted 3,4-dihalo-2(5H)-furanone compounds had been synthesized by dehydration etherification reaction with mucochloric acid(or mucobromic acid)and alcohol(or phenol)in toluene with the yields of 43～89％. The difference of yields might be related to their etherification mechanisms. The structures of the obtained compounds were characterized by 1 H NMR,13 C NMR,EI-MS,IR,UV and elemental analysis. The design and synthesis of these compounds with different biologically active groups provided a reference for the synthesis of novel 2(5H)-furanone derivatives and their use in test of biological activity or as organic intermediates as well as the synthesis of mixed ether compounds from different hydroxyl compounds.
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