利福霉素类和异烟肼是用于临床的一线抗结核药物,沃尼妙林为新一代半合成截短侧耳素类抗生素.本文通过杂合方法,成功合成了新杂合分子利福霉素异烟肼和利福霉素沃尼妙林.通过IR,1 H NMR,13 C NMR对它们的结构进行了表征;生物活性测定初步结果表明其具有较好的抗菌活性.%Rifamycin class of drugs and isoniazid(INH)are anti-TB first-line drugs in clinical. Valnemulin is a new generation pleu-romutilin class of semi-synthetic antibiotics. In this letter,with rifamycin,valnemulin and isoniazid molecules as the study subject, the new hybrid antibiotic structures for rifamycin-isoniazid and rifamycin-valnemulin we devised. Their structures were characterized by IR,1 H NMR,13 C NMR. The preliminary bioassay tests showed that they exhibited a good biological activity.
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