In this paper,3,4,5-trimethoxyphenol was directly acylated with p-methoxycinnamoyl chloride to give corresponding chal-cone in the presence of BF3-Et2O complex by Friedel-Crafts reaction. Under the action of I2/DMSO,5,6,7,4'-tetramethoxylflavone was obtained by intramolecular cyclization of chalcone. Finally,the demethylation of 5,6,7,4'-tetramethoxylflavone was performed to give the desired scutellarein in the overall yield of 54%. The structures of all compounds were confirmed by IR,'H NMR and MS. The method was concise, efficient and had a wide range of applications.%本文以3,4,5-三甲氧基苯酚与对甲氧基肉桂酰氯为原料,在三氟化硼-乙醚络合物催化下,发生Friedel- Crafts反应,生成9-羟基-5,6,7,4’-四甲氧基查尔酮；然后9-羟基-5,6,7,4’-四甲氧基查尔酮在碘的二甲基亚砜溶液中发生分子内环合得到5,6,7,4’-四甲氧基黄酮；最后在酸性条件下,5,6,7,4’-四甲氧基黄酮发生去甲基化水解反应制得野黄芩素,总产率达到54％.化合物结构经IR,1H NMR和MS表征.该方法简单易行,具有广泛的应用前景.
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