Speetrophotometric study on the charge-transfer reaction between perphenazine , the electron donor , and cresol red , the electron acceptor , was made , and based on this charge-transfer reaction , a photometric method for determination of perphenazine was proposed. Results showed that a charge transfer complex with composition ratio of 1 :2 was formed by the reaction between perphenazine and cresol red in acetone solution at room temperature. Showing its absorption maximum at the wavelength of 434 nm and apparent molar absorptivity of complex was 1.19 × 104L · mol-1 ·cm-1. Beer's Law is obeyed in the range of 2 ～60 mg · L-1 of perphenazine with correlation coefficient of 0. 9998. Precision of the method was tested at the concentration level of 20 mg· L-1 for 11 multiplieate determinations, and relative standard deviation was 0. 74 ％. The proposed method was applied to the determination of perphenazine in its tablets, giving results in consistency with the labelled value. Recovery of the method was tested by standard addition method, and values of recovery found were in the range of 99.5％ to 104. 4 ％ .%采用光度法研究了电子给予体奋乃静与电子接受体甲酚红之间的荷移反应,据此建立了荷移光度法测定奋乃静含量的方法.实验表明,奋乃静与甲酚红在丙酮介质中,室温条件下即可形成稳定的1:2型荷移络合物,该络合物的最大吸收波长为434nm,表观摩尔吸光系数为1.19×10<'4>L·mol<'-1>·cm<'-1>.奋乃静的质量浓度在2～60mg·L<'-1>范围内符合比尔定律,相关系数为0.9998.当奋乃静的质量浓度为20mg·L<'-1>时,测定结果的相对标准偏差(n=11)为0.74%.采用本方法测定了片剂中的奋乃静含量,平均回收率在99.5%～104.4%之间.
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