在干燥非质子性溶剂中,以3,6-桥-亚甲基-1,2,3,6-四氢邻苯二甲酰氯与N-(3-氨基丙基)眯唑和1-氨基-4-甲基哌嗪为原料,合成了两种降冰片烯桥联双酰胺化合物,并考察了反应温度、溶剂及缚酸剂对酰氯氨解反应的影响,目标化合物结构经核磁共振氢谱、核磁共振碳谱、红外光谱及元素分析进行表征确证.%Two norbomene-bridged bis-amides were synthesized by the reaction with trans-3, 6-endo-methylene-l, 2, 3, 6tetrahydrophthaloyl chloride, N-(3-aminopropyl)imidazole and l-amino-4-methylpiperazine as the staring materials in anhydrous aprotie solvent, and structurally characterized by 1H & 13C NMR, FT-IR and elemental analysis. The effects of reaction temperature, solvent and acid binding agent were investigated.
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