To find the relationship among IL-1、IL-6、TNF-α content in blood sera of HP-PRRSV infected pigs,so to explain the pathogenesis of HP-PRRS,and to provide a theoretical basis for the prevention and control of HP-PRRS,48 blood sera samples from 4 farms in Chengdu were sampled and tested by ELISA,including 25 RT-PCR positive samples with clinical symptoms and 11 positive samples without clinical symptoms and 12 negative samples. The results showed that the difference of IL-1 in positive pigs was significant(P<0.01) compared with the other two groups,and the dif-ferences of IL-1 between the other two groups were not significant(P>0.01) . The differences of IL-6 levels among the three groups were significant(P<0.05),and IL-6 in positive samples with clinical symptoms were higher(P<0.05) than the other two groups. The differences of of IL-6 in the other two groups with negative results were not significant(P>0.05). The differences of TNF-α among the three groups were not significant(P>0.05). These results showed that IL-1and IL-6 increased in blood serum when pigs were infected by HP-PRRSV and played important role in infection, while TNF-α has little change.%本试验旨在探究高致病性蓝耳病（HP-PRRS）自然病例中致炎因子IL-1、IL-6和TNF-α含量，进而阐述HP-PRRS的致病机理，为养殖生产中的HP-PRRS防控提供理论基础。在成都地区4个发病猪场采集具有临床症状的猪血清（含5头濒死猪）35份与无临床症状猪血清23份，利用RT-PCR分别检测出HP-PRRSV阳性血清25份和11份。将检测出阳性表现症状的25份血清、检测阳性无临床症状的11份血清及检测阴性的12份血清分成3组，分别标注为病猪组、隐性感染组和健康对照组，运用ELISA方法进行IL-1、IL-6和TNF-α含量测定。结果显示，IL-1含量在三组中差异极显著（P<0.01），病猪组极显著高于隐性感染组与健康组（P<0.01），隐性感染组与健康对照组差异不显著（P>0.05）；IL-6含量在三组中差异显著（P<0.05），病猪组显著高于隐性感染组与健康对照组（P<0.05），隐性感染组与健康对照组差异不显著（P>0.05）；TNF-α含量在三组之间无显著差异（P>0.05）。该结果表明IL-1与IL-6在HP-PRRS感染致病中具有重要作用。
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