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《中国化学快报:英文版》
>A NEW BIFUNCTIONAL CHELATING AGENT α,ε-N,N'-BIS(L-CYSTEINYL)-L-LYSINE FOR RADIOLABELLING OF MONOCLONAL ANTIBODIES WITH TECHNETIUM-99M
A NEW BIFUNCTIONAL CHELATING AGENT α,ε-N,N'-BIS(L-CYSTEINYL)-L-LYSINE FOR RADIOLABELLING OF MONOCLONAL ANTIBODIES WITH TECHNETIUM-99M
α,ε-N,N’-bis(L-cysteinyl)-L-lysine was synthesized and char-acterized for the first time.It was then employed as a bifunctional chelatingagent to chelate technetium-99m and subsequently conjugated to fragmentF(ab’)2 of anti-gastric tumor monoclonal antibody 3G9.The radiolabelledantibody was satisfactorily stable and immunoreactive.
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