Objective To investigate the efifcacy of photodynamic therapy (PDT) and intravitreal injection with ranibizumab on idiopathic choroidal nevasularization (CNV). Methods There were patients (30 eyes) who were diagnosed as idiopathic CNV. Randomly separate them into PDT group and combination group. We analyzed the changes in best corrected visual acuity and central macular thickness before and 1,3mo after the treatment. Results One month and three month after the treatment in PDT group and combination group: the BCVA increased while the CMT decreased compared with that of pretreatment (P<0.05), changes of BCVA and CMT showed statistically significant between two groups (P<0.05). Compared 3mo with 1mo after treatment: there was no significant difference in the BCVA and CMT changes (P>0.05). Conclusion Not only PDT but also PDT combined with inravitreal injection of ranibizumab could reduce the danger of causing descent of vision. Effects and the stability of the combination therapy was superior to PDT treatment.%目的：评价光动力疗法（photodynamic therapy, PDT）联合玻璃体腔注射雷珠单抗治疗特发性脉络膜新生血管(idiopathic choroidal neovascularization，简称特发性CNV)的临床疗效。方法临床确诊为活动期特发性CNV患者30例30眼，随机分为PDT治疗组（PDT组）及PDT联合玻璃体腔注射雷珠单抗治疗组（联合组）。对比分析治疗前及治疗后1,3mo患者最佳矫正视力（best corrected visual acuity, BCVA）及黄斑中心厚度（central macular thickness, CMT）变化。结果治疗后1mo，3 mo分别与治疗前相比：PDT组及联合组BCVA平均值均提高，CMT平均值均降低，差异具有统计学意义（P＜0.05）；两组间比较BCVA变化及CMT变化差异具有统计学意义（P＜0.05）。治疗后3mo与1mo相比：PDT组与联合治疗组BCVA平均值、CMT平均值差异均无统计学意义（P＞0.05）。结论 PDT治疗与PDT联合玻璃体腔注射雷珠单抗治疗均可减少CNV引起的视力下降；联合治疗的效果及稳定性要优于单纯的PDT治疗。
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