目的：探讨氯吡格雷抵抗对高龄冠心病合并糖尿病患者冠脉介入治疗效果的影响与相关因素分析。方法选择我院120例行冠脉介入治疗的冠心病高龄患者，将其分为冠心病高龄组和冠心病高龄合并糖尿病组，两组均服用氯吡格雷进行治疗，比较两组患者治疗后的糖、脂代谢，心肌梗死率和死亡率。结果冠心病高龄合并糖尿病组患者的FPG和GSP水平明显高于冠心病高龄组，HDL-C水平低于冠心病高龄组（P＜0.05），且术后心肌梗死率明显高于冠心病高龄组（P＜0.05），而两组死亡率无较大差异（P＞0.05）。结论高龄冠心病合并糖尿病患者有较明显的氯吡格雷抵抗现象，且术后心肌梗死风险较高。FPG和GSP水平的升高，HDL-C水平的下降是引起氯吡格雷抵抗的因素。%ObjectiveTo study the clopidogrel resistance of senile coronary heart disease patients with diabetes mellitus coronary interventional therapy effect and related factors analysis.Methods Choose 120 routine coronary interventional therapy of coronary heart disease, diabetes mellitus elderly patients, two groups were treated with clopidogrel treatment, compared two groups of patients after treatment of sugar, lipid metabolism, myocardial infarction rate and mortality.ResultsThe elderly patients with coronary heart disease complicated with diabetes mellitus group, FPG and GSP levels rate was signiifcantly higher than that of coronary heart disease in elderly group (P<0.05), and no significant difference between the two groups in mortality (P>0.05).Conclusion Elderly patients with coronary heart disease, diabetes mellitus have the obvious FPG and GSP level rise, a decrease in the level of HDL-C is the causes of clopidogrel resistance..
展开▼
