Objective To study the clinical effect of nerve growth factor in the treatment of patients with diabetic gastroparesis.Methods Selected 100 patients with diabetic gastroparesis in our hospital as research object, were divided into the insulin group(the control group) and the insulin and nerve growth factor group (the observation group), each group had 50 cases, then the clinical total effective rate after the treatment at fourth week and gastric half-emptying time, insulin resistance index(IRI), fasting blood-glucose (FBG), tumor necrosis factor-α(TNF-α), C reaction protein (CRP), high density lipoprotein (HDL-C) before and after the treatment at fourth week of two groups were detected and compared.Results The clinical total effective rate of the observation group after the treatment at fourth week were higher than the control group, gastric half-emptying time, IRI, FBG, TNF-αand CRP were all lower than the control group, HDL-C were higher than those of control group,P＜0.05, was difference had statistically significance.Conclusion The clinical effect of nerve growth factor in the treatment of patients with diabetic gastroparesis is better, and which improve the gastroparesis state and related indexes.%目的 探讨糖尿病胃轻瘫患者应用神经生长因子治疗的临床效果.方法 选取我院100例糖尿病胃轻瘫患者为研究对象,随机分为胰岛素组(对照组)和胰岛素加神经生长因子组(观察组),每组50例,将两组患者治疗结束后4周的临床总有效率及治疗前、治疗结束后4周的胃半排空时间、胰岛素抵抗指数(IRI)、空腹血糖(FBG)、肿瘤坏死因子α(TNF-α)、C反应蛋白(CRP)、高密度脂蛋白胆固醇(HDL-C)进行检测及比较.结果 观察组治疗后4周的总有效率高于对照组,而胃半排空时间短于对照组,IRI、FBG、TNF-α、CRP均低于对照组,HDL-C高于对照组,P＜0.05,差异具有统计学意义.结论 糖尿病胃轻瘫患者应用神经生长因子治疗的临床效果较好,可改善胃瘫的状态及相关指标.
展开▼
