目的：探讨米卡芬净(MCM﹚治疗儿童血液肿瘤并侵袭性真菌感染的疗程。方法方便选取2013年9月―2015年8月泉州市第一医院对血液肿瘤35例化疗期间合并侵袭性真菌感染(IFI﹚,随机分成A、B两组应用MCM治疗。对比评价A组16例疗程6周与B组19例疗程8周的疗效。记录两组治疗后CT、B超等影像学的改变,G/GM实验、血培养等实验室检查转阴时间。结果两组治疗6周时两组共17例痊愈,9例显效,痊愈率48.6%,显愈率77.1%。在8周时18例痊愈,8例显效,痊愈率51.4%,显愈率74.3%。第8周末时,疗程6周显愈率68.8%,疗程8周显愈率78.9%。两组治疗效果比较差异无统计学意义(P>0.05﹚。结论 MCM治疗IFI疗效高；疗程6周痊愈者,可不延长疗程。显效者适当延长疗程。%Objective To investigate the efficacy of micafungin(MCM) in treatment of children with hematological tumor and invasive fungal infection. Methods Convenient selection divided into A, B two groups of treating with MCM during the peri-od of chemotherapy of children with hematological tumor patients from September 2013 to August 2015 in Quanzhou First Hospital..Evaluat the efficiency of treatment between group A(16 cases in 6 weeks﹚ and group B(19 cases in 8 weeks﹚with invasive fungal infection(IFI) treated Results The two groups after 6 weeks of treatment in two groups of 17 cases were cured, 9 cases were effective, the cure rate was 48.6%, efficiency of 77.1%. At 8 weeks, 18 cases were cured, 8 cases were effec-tive, the cure rate was 51.4%, efficiency of 74.3%. At the end of the eighth week course of 6 weeks, the effective rate was 68.8%, the effective rate was 78.9% for 8 weeks(P>0.05﹚. Conclusion MCM therapy is effective in the treatment of IFI;treatment of 6 weeks recovery,may need have to prolong the course. Effective in the treatment might to extend the period.
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