目的：研究分析克林霉素用药的不良反应特点以及用药的安全性情况。方法选择该院从2012年10月—2013年10月收治的120例使用克林霉素后出现不良反应的患者，对所有患者的临床资料进行回顾性分析，对克林霉素的用药情况进行综合分析和研究。根据克林霉素引发的不良反应涉及的器官和系统，对不同患者的具体病情进行相应的处理措施。结果在所有不良反应中，过敏反应的发生率最高，达到34.17%，最低为泌尿系统，为5.00%，差异有统计学意义（P<0.05）。在给药途径中因为静脉滴注而导致不良反应的患者有93例，发生率为77.5%。与其他给药途径发生率的差异有统计学意义（P<0.01）。联合使用甲硝唑与环丙沙星的用药引发不良反应的患者比较明显，均为3例，占患者数的18.75%，而其他联合用药主要引发轻微的皮肤和胃肠道反应。结论医护人员在临床工作过程中需要对于克林霉素的合理运用加用足够的关注，并且做好相应的防护工作，尽量降低克林霉素的不良反应发生率，提高临床用药的安全性。%Objective To analyze the characteristics of adverse reactions of clindamycin and the safety of the drug. Methods 120 cases with adverse reactions after using clindamycin admitted in our hospital from October 2012 to October 2013 were selected. The clinical data of all the patients were analyzed retrospectively; the use of clindamycin was analyzed and studied comprehensively. The specific condition of the patients was treated correspondingly according to the organs and systems involved by the adverse reactions of clindamycin. Results Of all the adverse reactions, the incidence of allergic reaction is the highest, reaches 34.17%, the lowest is the incidence of urinary system, which is 5.00%, the difference is significant (P<0.05). Of the routes of administration, 93 cases with the adverse reactions due to intravenous drip, the incidence is 77.5%, the difference in the incidence of adverse reactions caused by intravenous drip and other routes of administration is statistically significant ( P<0.01). Adverse reactions caused by combined with metronidazole and ciprofloxacin drugs in patients is more noticeable, are all 3 cases, accounting for 18.75% of the number of patients, while other combination mainly cause slight skin and gastrointestinal reaction. Conclusion Medical staff should pay enough attention to the reasonable use of clindamycin in clinical work, and do a good job in the corresponding protection so as to reduce the incidence of adverse reactions of clindamycin and improve the safety of clinical medication.
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