Objective: To investigate the development of the mottled hypopigmentation induced by low-fluence large-spot-size Q-switched 1064 nm Nd:YAG laser in the treatment of melasma.Methods: One hundred and eighty patients with melasma treated with the Q-switched 1064 nm Nd:YAG laser for more than 5 times were followed up for 2 years.Results: Out of 180 patients with melasma, fifteen patients (8.33%) presented with mottled hopopigmentation.The hypopigmentation lesions recoveried in one case after 2 years, improvement in 2 and no change in 13.Conclusion: The mottled hypopigmentation induced by the low-fluence large-spot-size Q-switched 1064 nm Nd:YAG laser can persist for more than two years.%目的:了解大光斑低能量模式Q开关1064 nm激光治疗黄褐斑后所致点状色素减退恢复情况.方法: 对大光斑低能量模式Q开关1064 nm Nd:YAG激光治疗5次以上的180例黄褐斑患者随访2年.结果: 15例出现点状色素减退(8.33%),2年后1例痊愈,2例有改善,13例无变化.结论: 大光斑低能量Q开关1064 nm激光治疗黄褐斑所致的点状色素减退斑可持续2年以上.
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