目的：：检测内蒙古汉族寻常型银屑病GJB2基因rs72474224位点的多态性。方法：提取294例寻常型银屑病患者及287名正常对照外周血DNA,利用PCR和连接酶检测反应检测GJB2基因rs72474224的多态性。结果： SNP rs72474224等位基因T 在病例组和对照组中的频率分别为0.03571和0.01045,差异具有统计学意义( P＝0.004267)。结论： GJB2基因多态性rs72474224可能与内蒙古汉族人群寻常型银屑病的易感性相关。%Objective: To detect the polymorphisms of GJB2 gene rs72474224 in patients with psoriasis vulgaris in Han population in Inner Mongolia. Methods:DNA was extracted from the peripheral blood of 294 patients and 287 controls. The polymorphisms of GJB2 gene rs72474224 were genotyped by PCR-based ligase detection reaction ( PCR-LDR) . Results:The genotype frequencies of T in patients and controls were 0.0357 and 0.01045, with a significant difference (P=0.004267). Conclusion: The polymorphism of GJB2 gene rs72474224 is associated with psoriasis vulgaris in Han population in Inner Mongolia.
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